It has been shown that the isolated rat duodenum relaxes in the presence of low concentrations of plasma and urinary kinin. The tissue is at least as sensitive as the rat uterus. Vasopressin and oxytocin, in large doses, also caused relaxation of the duodenum whereas acetylcholine, substance P and 5-hydroxytryptamine caused contraction. It was concluded that if an extract is assayed on the rat uterus and the rat duodenum in parallel using plasma kinin as a standard, and the results agree, this is good evidence that the active principle being estimated is a kinin. This method is therefore both sensitive and specific for kinin estimations, but it will not distinguish between kinins of different origin. The urinary excretion of kinin in 14 healthy adults was found to be fairly constant. The minute output was unaffected by the rate of urine formation, urinary pH, or time of day. There was no increase during sweating or salivation.
No clinical trial protocols linked to this paper
Clinical trials are automatically linked when NCT numbers are found in the paper's title or abstract.PICO Elements
No PICO elements extracted yet. Click "Extract PICO" to analyze this paper.
Paper Details
MeSH Terms
Associated Data
No associated datasets or code repositories found for this paper.
Related Papers
Related paper suggestions will be available in future updates.