Ameloblastomas: clinical-histopathological evaluation of 85 cases with emphasis on squamous metaplasia and keratinization aspects.

OBJECTIVES: Ameloblastoma is a benign odontogenic neoplasm with an origin reputed to reactivation of odontogenic structures. Histological classification is based on microscopic features and architectural distribution of neoplastic cells. The importance of squamous metaplasia and keratinization has been disputed in ameloblastomas. Clinical and histopathological aspects were evaluated of 85 ameloblastomas, with attention to keratinization and squamous metaplasia features. STUDY DESIGN: Clinical-demographical information of 85 ameloblastomas were gleaned from the medical records. Microscopic analysis of all cases was carried out with emphasis on keratinization aspects of each tumor. RESULTS: Most ameloblastomas (54.12%) were diagnosed in males with a mean age of 37 years. Fifty-six patients were Caucasians (65.88%) and the mandible was affected in 68 (89.4%) cases. Most cases analyzed presented areas of squamous metaplasia/keratinization. Recurrence was detected in 16 cases; this was not related to keratinization aspects of the tumor. CONCLUSIONS: Keratinization is a common feature in ameloblastomas with no impact in tumor behavior.