2014 International journal of surg…

Oral fibroma with HPV-associated epithelial dysplasia: even in fibromas you should look for the unexpected.

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International journal of surgical pathology Vol. 22 (3) : 248-9 • May 2014

Fibromas are the most common soft tissue lesions of the oral cavity and are generally attributed to trauma. Koilocytic dysplasia refers to human papillomavirus (HPV)-related epithelial cytopathic effect. Koilocytic dysplasia is considered neoplastic. Herein, we report a case of oral fibroma with HPV-induced dysplastic changes of the surface epithelium confirmed by immunohistochemical stains for p16 and p53 as well as HPV in situ hybridization.

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