BACKGROUND: Relation between secretory immunoglobulin A (SigA) and dental caries still imprecise. Studies have been conducted either for total SIgA or mutans specific SIgA with bizarre results. AIM: The aim of this study is to find out the relationship between mutans antigen specific SIgA and total salivary SIgA and its influence in caries status in children. MATERIALS AND METHODS: A total of 45 children aged between 6-14 years were divided based on their caries index (decayed, missing, filled, extracted tooth) score in high moderate and no caries group and their saliva were analyzed with enzyme linked immunosorbent assay for total SIgA and mutans specific SIgA. RESULTS: High caries group showed high mutans specific SIgA, but less total SIgA, whereas low caries group showed the reverse. CONCLUSION: The mutans specific SIgA and total SIgA has a weak, but negative correlation in children potentiating caries inhibitory action of SIgA.
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