Study on application of ultrasound microbubbles in the diagnosis of buccal carcinoma and metastatic cervical lymph nodes in mice.

BACKGROUND: This project's aim was to explore the enhancing effect of contrast media on primary cancer and cervical metastatic lymph nodes of cheek carcinoma by local injection. MATERIALS AND METHODS: Lymphatic metastasis cheek carcinoma mice models were established, then self-made contrast media was administered into the primary cheek carcinoma and harmonic mode imaging was performed to observe the enhancement of primary lesions and cervical metastatic lymph nodes. RESULTS: The echo intensity (EI) was compared. The detection rate of metastatic lymph nodes and inflammatory lymph nodes was 61% (17/28) and 50% (6/12) before contrast-enhanced ultrasound (CEUS) imaging and 82% (23/28) and 75% (9/12) after CEUS imaging. After CEUS imaging, the EI of primary cancer and cervical metastatic lymph nodes was significantly increased, (P<0.01). CONCLUSION: After injection of self-made contrast media via the primary lesion, it can enter the lymph duct and obviously enhance the effect of ultrasonography on cervical metastatic lymph nodes of cheek carcinoma.