BACKGROUND: Adamantiades-Behcet's disease is an immune-mediated vasculitis with relapsing course. It is characterised by the classic clinical trias of oral aphthous ulcers, genital ulcers and uveitis. HISTORY AND FINDINGS: A 37-year-old woman suffered from systemic Adamantiades-Behcet disease with recurrent uveitis, oral ulcers, genital ulcers, arthralgia, erythema nodosum and folliculitis. COURSE AND TREATMENT: Longterm interferon-alpha-2a (IFNalpha-2a) led to reduction of the clinical manifestations except for occasional occurrence of oral ulcers. One year after initiation of treatment however, the patient developed symptomatic hyperprolactinemia of unknown etiology. CONCLUSION: Even in otherwise successful treatment with IFNalpha-2a possible side effects and complications of treatment can affect the course. Mastodynia and hyperprolactinemia have not yet been described as potential side effects of IFNalpha-2a.
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