Accidental overextension of filling material during endodontic treatment may cause mechanical and chemical irritation of the adjacent tissue. In this case series, seven patients who complained of neurologic complication after overextension of canal filling material during endodontic treatment were presented. Overextensions of filling material into the surrounding tissues, such as the mandibular canal, bone marrow, and submucosal layer, were confirmed with panoramic radiograph and computed tomographic images. When patients complain of neurological disturbances after root canal treatment, proper radiographic images should be taken to verify any overextension of materials and to determine the specific location of the overfilled materials.
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