OBJECTIVE: To examine transforming growth factor beta 1 (TGFbeta1) gene polymorphisms in Turkish patients with nonsyndromic cleft lip with/without cleft palate (nsCL/P). METHODS: A total of 205 Turkish subjects were included; 80 nsCL/P patients and 125 unrelated control individuals. Analysis of gene polymorphisms was carried out by polymerase chain reaction and DNA sequencing. RESULTS: We found the substitution of a proline by a leucine at codon 10 (Pro10Leu) and the substitution of an arginine by a proline at codon 25 (Arg25Pro) in exon 1 of the TGFbeta1 gene in nsCL/P patients. CONCLUSION: This is the first report investigating prevalence of TGFbeta1 polymorphisms in Turkish patients with nsCL/P.
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