Systematic review and meta-analysis of congenitally missing permanent dentition: Sex dimorphism, occurrence patterns, associated factors and biasing factors.

PURPOSE: We aimed to summarize/analyze, comprehensively and for the first time, the literature on the prevalence of congenitally missing teeth (CMT) in males and females and the CMT pattern, taking various associated and biasing factors into account. METHODS: A search was performed independently by two authors during September 2012 till June 2013 to find all the available literature regarding CMT-associated factors and patterns comprising sex dimorphism, arches, anterior/posterior regions, unilateral/bilateral patterns, and involved teeth. The data were statistically analyzed. RESULTS: Seventy-four studies were included. The mean CMT prevalence was 6.42+/-2.76% in males and 7.55+/-2.67% in females. Overall, CMT is more prevalent in females but only in epidemiological samples, and not in orthodontic or dental patients. Enrolling orthodontic/dental patients might increase the observed CMT in boys and/or reduce it in girls. Gender dimorphism was not affected by any of the factors: time, regions, or the biasing factors. There is not a significant predominance of maxillary or mandibular involvement, although the anterior segment is more likely to be affected. CONCLUSIONS: CMT is more common in girls and in the anterior segment, regardless of the date of publication. Contrary to the commonly held belief regarding more CMT prevalence in female orthodontic patients, it was shown that in dental/orthodontic patients, CMT prevalence is higher in boys.