OBJECTIVE: The purpose of this study was to investigate the effect of the heparanase inhibitor OGT2115 on the tumorigenic properties of KB oral cancer cells. MATERIALS AND METHODS: We treated KB cells with different concentrations of OGT2115. Then proliferation, invasion, and migration were detected using different assays. Cell cycle was explored using flow cytometry. RESULTS: We found that the treatment inhibited proliferation, invasion, and migration in a dose-dependent manner. OGT2115 also increased the apoptosis of KB cells and blocked cell cycle in S-phase. CONCLUSIONS: Our results support the use of the heparanase inhibitor OGT2115 to inhibit several tumorigenic activities of KB oral cancer cells.
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