BACKGROUND: Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression. AIM: To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC. MATERIALS AND METHODS: 11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens. STATISTICAL ANALYSIS: Differences between the different variables were analyzed using ANOVA test, Kruskal-Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version 19. RESULTS: The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades. CONCLUSIONS: The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.
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