[Effect of a non-thermal atmospheric pressure argon plasma jet on SOD and MDA levels in oral mucosal ulcer of golden hamsters].

PURPOSE：To observe the effects of a non-thermal atmospheric pressure argon plasma jet on the healing time, and the levels of superoxide dismutase（SOD）and malondialdehyde（MDA）in oral mucosal ulcer of golden hamsters．METHODS： 56 golden hamsters were randomly assigned to 8 groups, one normal control group, one ulcer group, one natural healing group without any therapy, one iodine glycerin group, two argon groups (30 s, 120 s)and two plasma groups (30 s, 120 s)．24 hours after the last treatment, 4 hamsters from each group were sacrificed to detect SOD and MDA levels in the oral mucosal ulcer by spectrophotometry. The healing time in the remaining hamsters was observed continuously for 9 days after the last treatment．The data were analyzed with SPSS 22.0 software package. RESULTS：The healing time of the plasma groups was significantly shorter than the other groups (P=0.00). 24 h after the last treatment, there was no significant difference between the plasma groups and the normal contro1 group in SOD and MDA levels (P>0.05), SOD level in plasma groups was significantly higher than other groups (P=0.00), and MDA level in plasma groups was significantly lower than other groups (P=0.00). There was no significant difference between 30 s and 120 s plasma group in SOD and MDA levels (P>0.05). CONCLUSIONS: Non-thermal atmospheric pressure plasma in certain dose can increase SOD level and decrease MDA level in ulcer tissues effectively, and reduce the healing time of oral ulcer in golden hamsters．.