[Short-term effect of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis].

PURPOSE: To explore the short-term effects of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis. METHODS: Twenty subjects with severe chronic periodontitis but otherwise healthy participated in the study and they were divided into two groups randomly. The patients in the experimental group took ibuprofen 300mg, bid for 5 days after scaling and root planing (SRP), while patients in the control group only underwent SRP. Clinical indexes were recorded at baseline, 1 w, 2 w, 4 w, respectively. Meanwhile, the levels of tumor necrosis factor alpha (TNF-alpha), osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) in the gingival crevicular fluid were detected. SPSS 17.0 software package was used for statistical analysis. RESULTS: At each time point, both the clinical data and the levels of TNF-alpha, RANKL, OPG and RANKL/OPG between the experimental group and the control group were not statistically significant (P>0.05). CONCLUSIONS: We can't disclose the positive effect of ibuprofen's short-term oral administration on the treatment of severe chronic periodontitis.