[Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review].

OBJECTIVE: This study  aims  to  assess  the  remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by  performing  system review of  randomized  controlled  trials (RCT) involving  the  treatment of enamel demineralization with  CPP-ACP. METHODS: The study  was  developed  based  on  the 
Cochrane handbook  for  systematic reviews of  interventions (Version 5.1.0) and included  the  following: search strategy, selection  criteria, data  extraction, and  risk  of  bias  assessment. We  searched electronic  databases  such  as  PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up  to  September  2016. RCT of  treating  enamel demineralization with  CPP-ACP were  included. Data  extraction  and domain-based  risk  of  bias  assessment  were independently  performed  by two  reviewers. RESULTS: Twelve  RCTs  were  included.  Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out. CONCLUSIONS: There is no strong evidence that CPP-ACP is superior to conventional fluoride formulations in enamel remineralization. However, due  to the limitations of sample size, follow-up time and study design,  more high quality and large-sample RCT are needed to  further verify  the evidence.