Peripheral giant cell granuloma: An updated analysis of 2824 cases reported in the literature.

OBJECTIVE: To integrate the available data published on peripheral giant cell granuloma (PGCG) into a comprehensive analysis of its clinical/radiological features. MATERIALS AND METHODS: An electronic search was undertaken in January 2018 in 5 databases, looking for publications reporting cases of PGCGs. Probability of recurrence was calculated for some variables. RESULTS: A total of 165 publications were included, 2824 lesions identified. PGCGs were slightly more prevalent in women and more prevalent in mandibles, usually asymptomatic, and presenting erosion of the subjacent bone in almost one-third of cases. Additional curettage (2.8%) or peripheral osteotomy (0%) after excision presented lower recurrence rates in comparison with excision alone (16%). Excision followed by curettage decreases the probability of recurrence by 85% in comparison with excision alone. Other factors (age, lesion size, follow-up, gender, location, clinical symptoms, bone erosion) seem to do not influence the probability of recurrence. CONCLUSIONS: As surgical excision alone shows a considerable recurrence rate, excision followed by an additional therapy-curettage or peripheral osteotomy-should be the first choice of treatment of PGCG.