[The expression and significance of S100A9 in oral squamous cell carcinoma].

Objective:This research intended to explore the expression levels of S100A9 protein in oral squamous cell carcinoma (OSCC), and to analyze its relation with clinicopathologic features in OSCC, then discuss its clinical significance in diagnosis and prognosis of OSCC. Method:Using immunohistochemistry and Western blot to examine S100A9 in 35 oral squamous cell carcinoma specimen and 30 normal oral tissue as control.Result:Expression of S100A9 in oral squamous cell carcinoma (77.1%) was obviously higher than that in normal organizations (46.7%, P< 0.05 ). Among it, expression of low differentiated group was higher than that of high differentiated group. Expression of oral squamous cell carcinoma group in Ⅲ-Ⅳ period was higher than that of Ⅰ-Ⅱ period. The above differences were statistically significant. Expression of S100A9 was not associated with patients'age and gender (P> 0.05). The difference had no statistical significance.Conclusion:Overexpression of S100A9 protein may play a vital role in the progression of OSCC, which can be served as a positive marker for the diagnosis and prognosis of OSCC.