MRI assessment and histopathologic evaluation of subchondral bone remodeling in temporomandibular joint osteoarthritis: a retrospective study.

OBJECTIVE: The aim of the study was to characterize subchondral bone remodeling by using magnetic resonance imaging (MRI) and histopathologic assessment of temporomandibular joint osteoarthritis (TMJOA) and to analyze the correlations between them. STUDY DESIGN: The retrospective study was based on 153 joints of 100 patients. These patients had undergone MRI and had been diagnosed with temporomandibular joint internal derangement Wilkes stage IV-V, followed by the failure of conservative or arthroscopic/anchorage treatment. We evaluated and compared 136 joints based on MRI and histopathologic observation. According to the modified Osteoarthritis Research Society International system and the Diagnostic Criteria for Temporomandibular Disorders system, the scores of histopathology and MRI were compared by using kappa categorical agreement analysis. RESULTS: MRI showed subchondral bone changes in 153 joints, 136 of which had been subjected to surgical treatment and histopathologic assessment. Statistical tests revealed substantial agreement between MRI and histopathology (kappa value: 0.779). CONCLUSIONS: MRI is an effective technique to evaluate the pathologic changes of TMJOA. Our histopathologic grading criteria contributed to the clarification of the occurrence and developmental process of TMJOA. Therefore, the evidence of MRI should be seen as a reference standard for the choice of nonsurgical or surgical therapy in the management of TMJOA.