Targeted therapy as well as reduced adverse effects are the advantages of local drug delivery in dental caries. The application of nanotechnology in this context has gained increasing momentum during last years. A literature search here has provided a brief overview to present the recent developments in using nanoparticles for local treatment of dental caries. Nanoparticles as delivery systems, can entrap substances/drugs and use the advantages of small size and better penetration. They can also profit from biomimetic approaches to provide more effective treatment. Thoroughly, nanotechnology-based treatment of dental caries in situ, may introduce a novel aid in the field of dentistry.
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