Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis.

Objective: Molar incisor hypomineralization (MIH) is a kind of enamel hypomineralization. MIH has a serious negative impact on patient's oral health. Whether neonates with premature birth or low birth weight are susceptible to MIH has not been rigorously evaluated. The purpose of this systematic review and meta-analysis was to determine whether premature birth and low birth weight increased the possibility of developing MIH in neonates.Method: We searched relevant studies published from 2001 to June 2018 on PubMed and Embase. The methodological quality of the studies included in the meta-analysis was assessed using the Agency for Health Care Research and Quality (AHRQ) inventory tool.Results: Premature birth promoted the prevalence of MIH (OR = 1.57, 95%CI: 1.07-2.31). Low-birth-weight neonates were approximately three times likely to suffer from MIH (OR = 3.25, 95%CI: 2.28-4.62).Conclusions: Our finding suggests that premature birth and low birth weight increase the prevalence of MIH.