Effects of a compound vitamin B mixture in combination with GeneTime(R) on radiation-induced oral mucositis.

OBJECTIVE: Both compound vitamin B mixtures and GeneTime(R) have been used in treatment of oral inflammation. This study aimed to assess the therapeutic effects of a compound vitamin B mixture combined with GeneTime(R) on radiation-induced oral mucositis. METHODS: A total of 100 patients with radiation-induced oral mucositis were randomly divided into a control group (vitamin B alone; n = 50 patients) and an observation group (vitamin B plus GeneTime(R), n = 50 patients). Clinical outcomes were compared between the two groups for the following 3 weeks. RESULTS: The observation group had a significantly greater number of grade 0-I patients and significantly fewer grade II-IV patients than the control group. Among patients in the observation group, a significantly greater number of ulcers healed within 1-2 weeks, compared with those in patients in the control group. Significantly fewer ulcers healed among patients in the observation group at 3 weeks; notably, there were fewer ulcers to heal in the observation group, compared with the control group. CONCLUSIONS: Use of a compound vitamin B mixture combined with GeneTime(R) exerted obvious therapeutic effects on radiation-induced oral mucositis and markedly shortened ulcer healing time. Therefore, this strategy may be useful in clinical applications.