This study compared the cyclic fatigue resistance (CFR) of three controlled memory (CM) nickel-titanium rotary files (One Curve, EdgeFile and HyFlex CM) in comparison with a file (ProTaper Next) made from M-wire nickel-titanium alloy at two different temperatures (room and intracanal) in an s-shaped canal. One hundred and sixty files were tested to determine the CFR of OneCurve, EdgeFile, HyFlex CM and ProTaper Next in an artificial canal at room and at intracanal temperature. The number of cycles to failure was recorded, and data were analysed. At both temperatures, ProTaper Next exhibited the lowest CFR compared with the other files (P < 0.05). At room temperature, there was no difference among the three CM files regarding CFR (P > 0.05). At intracanal temperature, OneCurve and EdgeFile exhibited more CFR than the HyFlex CM (P < 0.05). Testing at intracanal temperature caused a significant decrease in CFR of all tested files compared with testing at room temperature.
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