OBJECTIVE: This in vitro study aimed to compare the cyclic fatigue resistance of HyFlex EDM (HEDM), Vortex Blue (VB), ProTaper Gold (PG), and OneCurve (OC) nickel-titanium (NiTi) instruments. MATERIALS AND METHODS: About 12 HEDM (25/.~), 12 VB (25/.06), 12 PG (25/.08), and 12 degrees C (25/.06) instruments were included in this study. All the instruments were tested with a 60 degrees angle of curvature and a 3-mm radius of curvature. All the instruments were utilized until fracture occurred, and then the number of cycles to failure (NCF) was calculated. The data were analyzed statistically using Kruskal-Wallis H and Mann-Whitney U-tests. The statistical significance level was set at P < 0.05. RESULTS: HEDM instruments had the highest cyclic fatigue resistance among all the other instruments (P < 0.05). The OC instruments had a significantly higher fatigue resistance than the PG and VB instruments (P < 0.05); however, there was no significant difference between PG and VB instruments in the NCF (P > 0.05). CONCLUSION: Within the limitations of this in vitro study, it was found that the cyclic fatigue resistance was higher for the HEDM instruments than for the VB, PG, and OC instruments.
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