STATEMENT OF PROBLEM: Denture adhesives are products used by wearers of removable dental prosthesis; however, systematic reviews on their influence on masticatory performance are lacking. PURPOSE: The purpose of this systematic review was to evaluate the efficiency of denture adhesives in improving the masticatory performance of users of complete dentures (CD). MATERIAL AND METHODS: This systematic review was organized from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist, and the methods were registered on the international prospective register of systematic reviews (PROSPERO-CRD42020187385). The focus question was as follows: "Does the use of denture adhesives improve the masticatory performance of patients with removable dental prostheses?" The databases PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library were used to extract information. RESULTS: The search yielded 1338 articles, of which 6 met the inclusion criteria and were selected. All included studies were crossover randomized controlled trials including bimaxillary edentulous individuals. Masticatory performance was evaluated by using a comminution and sieve method. CONCLUSIONS: Denture adhesives significantly increased the masticatory performance of CD users.
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