THE EFFECT OF MONOMER OF REMOVABLE DENTURE BASE RESIN ON THE STRUCTURAL ORGANIZATION OF THE GLANDULAR ZONE OF ALBINO RAT HARD PALATE IN THE EXPERIMENT.

OBJECTIVE: The aim: The paper presents the findings of the study of the 3 month-long effect of the monomer of the "Ftorax" denture base acrylic resin on the structural organization of the mucous membrane and the condition of the salivary glands of the albino rats' hard palate during the experiment. PATIENTS AND METHODS: Materials and methods:To achieve this goal, experimental studies involved mature rats, whose hard palate mucosa was smeared with 2% aqueous solution of the monomer of the "Ftorax" denture base acrylic resin twice a day in the morning and evening. The animals were sacrificed on day 30 of the experiment and following 3 months. RESULTS: Results: The findings of the studies of the structural organization of the mucous membrane and the analysis of the micropreparations of the mucous membrane of the hard palate of the animals of Group III have revealed substantial pathological changes both in the covering epithelium and in the lamina propria. The comparison between the intact animals and group of animals subjected to the 3 month-long effect of the monomer showed a significant thickening of the epithelial layer; a decrease in the mitotic index in the basal layer; impaired stratification of the cellular elements of the spinous layer; manifestations of exudative purulent inflammation, cystic and sclerotic changes in the excretory ducts; increase in the amount of connective tissue in the lobules of the salivary glands; decrease in the volume of the secretory parenchyma. CONCLUSION: Conclusions: Based on the findings of the study we can conclude that the prolonged effect of the monomer of the denture base acrylic resins leads to disorder of the structural organization of the glandular zone of the hard palate; in its submucous layer the total volume of the salivary glands decreases, which, in turn, significantly reduces secretion and leads to hyposalivation.