Applications of Computational Pathology in Head and Neck Cytopathology.

BACKGROUND: The application of computational technology to head and neck cytology material has been explored experimentally in several areas with a variety of potential applications. SUMMARY: This review summarizes the application of these techniques to the diagnosis of thyroid, salivary gland, and other head and neck fine-needle aspiration specimens. Current limitations and potential future applications in diagnosis are discussed along with the possibilities for therapeutic applications of computational methodology. Key Message: Particularly promising applications include resolving diagnostic uncertainty in indeterminate thyroid aspirates and assessing the tumor microenvironment in response to immunotherapy for squamous cell carcinoma.