[Comparison of the effects of dexmedetomidine and esmolol on controlled hypotension in patients with orthognathic surgery].

PURPOSE: To compare the effect of dexmedetomidine (Dex) and esmolol on controlled hypotension in patients with orthognathic surgery. METHODS: From January 2017 to December 2019, a total of 109 patients were treated with Dex (group D) and esmolol (group E) during orthognathic surgery (Le Fort I osteotomy of maxilla and sagittal split of mandibular ramus) in our hospital. Heart rate(HR) and mean arterial pressure(MAP) during controlled hypotension (the difference between the highest and lowest values and the percentage of basic values), intraoperative blood loss, allogeneic blood transfusion, operation time and dosage of propofol and remifentanil were compared between the two groups. The data were statistically analyzed using SPSS 22.0 software package. RESULTS: Compared with group E, HR and MAP, dose of propofol and remifentanil in group D were significantly lower than those in group E (P<0.05). There was no significant difference among other indexes. CONCLUSIONS: Compared with esmolol, the effect of Dex on controlled hypotension during orthognathic surgery is more stable and the dosage of propofol and remifentanil is decreased.