ASSESSMENT OF THE MICROBIAL CONTENT OF PERIODONTAL POCKETS IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS AND CORONARY ARTERY DISEASE.

OBJECTIVE: The aim: To study the rate of detection of specific periodontopathogenic microbiota in patients with chronic generalized periodontitis (CGP) and coronary artery disease (CAD) and assessment of the risk of periodontal pathogens in the development of CAD. PATIENTS AND METHODS: Materials and methods: A microbiological study of the content of periodontal pockets was carried out in 64 patients with CGP and CAD of the study group (mean age - 56.9+/-7.9 years) and 20 patients of the comparison group (mean age - 45.2+/-11,8 years) who were not burdened with CAD. RESULTS: Results: It was established that in patients with CGP and CAD the following periodontal pathogens were found more frequently than in the comparison group: Aggregatibacter actinomycetemcomitans (56.3+/-6.20% vs 25.0+/-9.68%; p=0.01), Prevotella intermedia (54.7+/-6.22% vs. 20.0+/-8.94%; p=0.01), and Fusobacterium spp. (34.4+/-5.94 vs. 10.0+/-6.71%; p=0.04). The increase in the percentage of the association of the periodontal pathogens was revealed in patients with CAD, which increased with the severity of the pathological process in periodontal tissues. The results of the study indicate the association of A. actinomycetemcomitans, P. intermedia, Fusobacterium spp. with CAD: A. actinomycetemcomitans: OR=3.86 (95% CI: 1.25-11.90), p=0.015; P. intermedia: OR=4.83 (95% CI: 1.45-16.05), p=0.007; Fusobacterium spp.: OR=4.71 (95% CI: 1.00-22.20), p=0.035. CONCLUSION: Conclusions: Analysis of the microbiological study indicates a high rate of detection of specific periodontal pathogens in patients with CGP and CAD. It can be assumed that the presence of such periodontal pathogens as A. actinomycetemcomitans, P. intermedia, Fusobacterium spp., significantly increases the risk of CAD.