A critical analysis of research methods and experimental models to study working length determination and the performance of apex locators - A narrative review with recommendations for the future.

Outcome studies have repeatedly shown that the apical endpoint of root canal preparation and filling is a determinate factor for the outcome of root canal treatment. Accurate determination of root canal length enhances the efficacy of chemo-mechanical disinfection and prevents over-/under-instrumentation and over-/under-filling in relation to the canal terminus. Long and short root canal fillings are consistently reported to be associated with higher rates of post-treatment endodontic disease. Although standards for undertaking and reporting diagnostic accuracy studies are available, publications dealing with the determination of root canal length are highly heterogeneous and describe procedures inconsistently. The aim of this review is to critically assess the methodology of publications in the past three decades. The process of planning, performing and analysing working length studies are presented stepwise with suggestions to optimize research methods.