Microvascular Decompression Versus Gamma Knife Surgery in Patients with Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis.

OBJECTIVE: There are 2 cardinal approaches for drug-resistant trigeminal neuralgia (TN), including microvascular decompression (MVD) and gamma knife surgery (GKS). This study aimed to compare the results of MVD versus GKS in the treatment of drug-resistant TN. METHODS: The search strategy was formulated in accordance with PRISMA recommendations for publications retrieved from electronic databases, such as PubMed, Scopus, and web of science. Inclusion and exclusion criteria were examined for relevant research. The meta-analysis was conducted by combining data using odds ratios. RESULTS: Four papers were included in our study. 582 patients were treated with MVD, and 607 patients were treated with GKS for drug-resistant TN. Findings revealed that MVD related to higher rates of pain relief and lower rates of pain recurrence compared to GKS. It seems that GKS had lower post-procedural complications in our review. CONCLUSIONS: MVD and GKS both reduce pain in patients with drug-resistant TN, but MVD was superior to GKS in pain relief. Furthermore, recurrence rate was lower. Post-operative complications except facial numbness were higher in MVD.