Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with pathognomonic histopathologic features of invading nests, islands, or chords of malignant epithelial cells. Although the histological features are quite uniform across a majority of the cases, they can drastically change in different variants of OSCC, such as clear cell, spindle cell/sarcomatoid, adenoid/acantholytic/pseudoglandular, basaloid, papillary and adenosquamous, etc.
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