BACKGROUND: To achieve the ultimate therapeutic reality of disease prevention, we must first conduct a thorough review of periodontal and peri-implant diseases concomitant with their mechanistic, predisposing, and precipitating factors to address the present oral/systemic needs of our patients. METHODS: An innovative dental research patient data repository (RPDR) named BigMouth was successfully launched in August 2012 with data on more than 4.5 million patients seen in 11 dental schools (members of the Consortium of Oral Health Research and Informatics, COHRI). RESULTS: Level 1 data access allots researchers with count data that may be used to formulate and test initial hypotheses based on preliminary data trends. Level 2 access gives more detailed, patient-level information with full periodontal charts. Of note, radiographic data were not accessible at the time of writing this manuscript. CONCLUSION: As we support the use of these innovative "big data" tools for exploratory use, we bring to the forefront the purposeful intention to (1) not overproject unsubstantiated relationships and (2) simultaneously pursue grounding of the mechanistic underpinnings of found associations.
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