CLINICAL-MORPHOLOGICAL SUBSTANTIATION OF THE FIBROUS MATRIX WITH BIOGEL CENO BONEcapital TE, Cyrilliccapital EM, Cyrillic APPLICATION FOR PRESERVATION OF THE ALVEOLAR PROCESS OF THE JAWS AFTER THE TEETH REMOVAL.

The aim of the study was to evaluate the possibility and effectiveness of fiber matrix use in order to maintain the original geometric parameters of the bony crest in the area of removed teeth. ; The experimental study was performed on laboratory animals (rabbits). 30 animals of the main group were implanted with a polymer matrix in the area of bone defect, 30 animals of the control group were formed bone defect. Patients in the study group were performed with filling-out of a post-extraction socket by fiber matrix developed by the authors of the article (small er, Cyrillicatent for invention of Ukraine numero sign 119958) in combination with biogel CenoBonesmall te, Cyrillicsmall em, Cyrillic. For patients in the control group filling or overlapping of the post-extraction socket were not conducted. Computed tomography was performed at the period of 4 months after the initial surgical intervention. Analysis of the parameters of bone tissue in the area of the removed teeth 4 months after extraction was performed on the basis of the tomography-results in the ImageJ software (Wayne Rasband (NIH)) using the specialized BoneJ plugin.; The results of experimental studies confirmed that percentage of osteoid in the main group, compared with the control indicators, showed a pronounced framework effect of the implanted microfiber polymer matrix. This fact was confirmed by the presence of complete mineralized bone tissue in the defect zone with lysis of the fibers of the non-woven polymer matrix and the presence of microosteoid foci, the proportion of which was 0.13% (small er, Cyrillic<0,05), which is 86% less than in the control group. ; The analysis of clinical studies showed that average level of resorption of the medial bone wall of the post-extraction socket was 0,6+/-0,4 mm (range of indicators - 0,3-0,8 mm), distal bone wall - 0,4+/-0,3 mm (range of indicators - 0,2-0,6 mm), vestibular bone wall - 1,4+/-0,7 mm (range of indicators - 0,9-2,0 mm), lingual bone wall - 1,2+/-0,7 mm (range of indicators - 0,8-1,9 mm). In the control group, the average level of bone resorption reached from the medial side 1,4+/-0,5 mm (range of indicators - 0,8-1,7 mm), from the distal side - 0,9+/-0,6 mm (range of indicators - 0,7-1,5 mm), from the vestibular side - 2,2+/-0,4 mm (range of indicators - 1,5-2,6 mm), from the oral side - 2,1+/-0,6 mm (range of indicators - 1,3-2,4 mm). In both groups the statistical difference between the change in the vertical parameters of the residual crest from the medial/distal sides and the vestibular/oral sides was noted (p<0,05). ; Obtained results indicate a more pronounced preservation effect of the using fiber matrix compared with the usual healing of the tooth extraction region, which was confirmed by the results of the tomography study. Thus, this approach can be recommended for implementation in practice to optimize the conditions for delayed implantation in the area of the teeth removed due to endodontic, periodontal, traumatic lesions or extensive caries pathology with the expression of inflammatory changes at the time of intervention.