Evaluation of pro-atherogenic lipid profile and high atherohenic indexes in patients with Behcet's disease: A case-control study.

BACKGROUND: Behcet's disease is a systemic auto-immune and auto-inflammatory chronic disease in which genetic and environmental factors play a role. Patients with Behcet's are at significant risk for developing many comorbidities, including cardiovascular diseases. AIMS: It was aimed to investigate the relationship between serum lipid parameters and atherogenic indexes to evaluate the cardiovascular risk status in patients with Behcet's disease. PATIENTS/METHODS: This study was designed as a single-center, retrospective case-control study. The study was conducted with 212 patients over 18 years of age, 106 in the case group and 106 in the control group. RESULTS: There was a significant difference in lipid values between the patients with Behcet's disease and the control group. While the serum triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (NHC) levels were significantly higher, the high-density lipoprotein cholesterol (HDL-C) level was low in patients with Behcet's disease. From atherogenic indexes, Atherogenic Index of Plasma (AIP) (0.03 +/- 0.27 vs. -0.07 +/- 0.23, p = 0.003), Castelli Risk Index I (CRI-I) (4.24 +/- 1.07 vs. 3.02 +/- 0.96, p < 0.001), Castelli Risk Index II (CRI-II) (2.65 +/- 0.81 vs. 1.84 +/- 0.59, p < 0.001) and Atherogenic Coefficient (AC) (3.24 +/- 1.07 vs. 2.02 +/- 0.96, p < 0.001) levels were significantly higher in patients with Behcet's disease. CONCLUSION: Our study shows that patients with Behcet's have a higher pro-atherogenic lipid profile and atherogenic indexes at high risk. Patients with Behcet's have an increased risk of cardiovascular diseases associated with atherosclerosis.