A bioactive and anti-bacterial nano-sized zirconium phosphate/GO (nZrP/GO) composite: Potential use as a coating for dental implants?

OBJECTIVE: Dental implants fabricated from titanium have several limitations and therefore, alternative materials that fulfil the criteria of successful dental implant (bioactivity and anti-bacterial activity) need to be considered. Polyether ether ketone (PEEK) has been suggested to replace titanium implants. However, this material needs surface modification to meet the appropriate criteria. A nano-sized zirconium phosphate/GO (nZrP/GO) composite coating was prepared to improve PEEK's biological qualities. METHODS: Polished and cleaned PEEK discs were coated with the composite of nZrP doped with 1.25 wt% GO by the soft-template method. To analyze the composite coating, X-ray, atomic force microscopy, and field emission scanning electron microscopy-energy dispersive spectroscopy were used. The adhesion of the coating to PEEK was measured by adhesive tape test. By measuring the optical contact angle, the coated and non-coated samples' differences in wettability were evaluated. Antimicrobial activity was evaluated against S. aureus and E. coli and cytotoxicity tested employing gingival fibroblasts and osteoblast-like cells. RESULTS: The nZrP/GO composite coating was 23.45 microm thick, was irregular and attached strongly to the PEEK surface. Following coating, the water contact angle dropped to 34 degrees and surface roughness to 13 nm. The coating reduced the count of bacteria two-fold and was non-cytotoxic to mammalian osteoblast-like cells and fibroblasts. A precipitation of nano-calcium-deficient apatite was observed on the surface of the nZrP/GO coating following a 28-day immersion in SBF. SIGNIFICANCE: PEEK-coated with nZr/GO coating is a good candidate as dental implant.