Is periodontitis triggering an inflammatory response in the liver, and does this reaction entail oxidative stress?

An inflammatory disorder known as periodontitis impacts 10%-15% of adults. The pathogenesis of periodontal disease and system illnesses such as liver disease is similar in that it is marked by a chronically dysregulated inflammatory reaction. Injuries caused by inflammation and oxidative stress, such as hepatotoxicity caused by drugs, often affect the liver. Nearly every disease has oxidative damage and inflammation as its primary components. Inflammation and direct activation of HSCs are mediated by reactive oxygen species (ROS). Major biological components, such as DNA, proteins, and lipids, are damaged by oxidative damage. ROS are crucial in activating the signalling channels of NF-kappaB and NLRP3. Oxidative damage occurs via ROS and NO and it triggers inflammatory reactions via IL-12, IL-1beta, IL-6, MIP-1alpha, IL-10, TNF-alpha, MCP-5, INF-gamma, IL-8, nitric oxide and prostaglandin E2 within the tissues, leading to tissue damage. Because oxidative damage is a major factor in chronic inflammatory conditions including gum disease and liver damage, recent epidemiological investigations have demonstrated a link among the two. This review has concentrated on the ways whereby periodontopathic microbes exacerbate liver illness and persistent inflammation through elevated oxidative damage.