Polymorphisms in nanog are associated with oral leukoplakia: case-control study.

To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia.