OBJECTIVE: This study aimed to analyze the DNA ploidy profile of pleomorphic adenoma (PA) using flow cytometry, with a particular focus on its malignant transformation. STUDY DESIGN: Tissue samples were obtained from normal glands, primary and recurrent PA, and carcinoma ex PA (CXPA) (residual PA and malignant areas) for analysis. The data were analyzed using dedicated software and relevant increased literature resources. RESULTS: The study revealed a decline in the number of cells in the G1 phase and an increase in those in the 5cER phase in CXPA compared to their benign counterparts. CONCLUSIONS: DNA content by flow cytometry could be a valuable tool to aid in detecting CXPA early and to differentiate it from PA when routine histologic features are insufficient.
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