INTRODUCTION: The present study aimed to clinically compare the incidence of postoperative pain after endodontic treatment of posterior teeth using XP-endo Shaper (XPES; FKG Dentaire, La Chaux-de-Fons, Switzerland) and TruNatomy (TNY; Dentsply Sirona, Ballaigues, Switzerland) systems. METHODS: In a single-blind randomized clinical trial, 104 vital teeth with an indication for conventional endodontic treatment for prosthetic purposes were treated by a single specialist following a pre-established protocol. All participants were unaware of the treatment they received. The teeth were randomly divided into 2 groups (n = 52) according to the instrumentation system used (TNY group and XPES group). The treatments were performed in a single visit. The participants were asked to rate the intensity of postoperative pain on a numeric rating scale and a visual analog scale (no pain, mild pain, moderate pain, and severe pain) after 24, 48, 72 h, and after 7 days. RESULTS: The incidence of postoperative pain was zero in both groups at 48 h, 72 h, and 7 days. At 24 h, most patients in the XPES and TNY groups had no pain, while the remaining participants in either group experienced mild pain (1-3), with no significant difference between groups (P > .05, Mann-Whitney test). CONCLUSIONS: The instruments used in this study are associated with minimal postoperative pain, which only occurred in the first 24 h. Based on the parameters analyzed, we conclude that the systems tested cause mild postoperative pain over a short period of time.
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