Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis.

OBJECTIVE: This review focuses on the clinical and preclinical studies pertaining to the use of phytochemicals in the prevention of Oral Squamous Cell Carcinoma (OSCC) metastasis. METHODS: A thorough overview of the relevant literature was provided by the narrative review approach. The PubMed, Google Scholar, and Scopus databases were used to retrieve publications on the phytochemicals preventing oral cancer metastasis. Clinical trials of phytochemicals on oral cancer patients were retrieved from https://clinicaltrials.gov/. RESULTS: An increasing number of scientific literature provides evidence suggesting that phytochemicals might possess the capacity to impede cancer invasion and metastasis. Plant extracts and phytochemical substances, including genistein, curcumin, lycopene, resveratrol, isothiocyanates, and green tea extract, have shown promise in recent novel research as potential weapons against this cancer. CONCLUSION: A crucial prognostic factor for oral cancer is distant metastasis (DM). Chemoprevention is a comprehensive concept that encompasses the use of synthetic or natural substances to impede the development or progression of cancer. This current literature review enumerates the data supporting these potential phytochemicals' benefits in OSCC.