Evaluating efficacy of laser-assisted new attachment procedure and adjunctive low-level laser therapy in treating periodontitis: A single-blind randomized controlled clinical study.

PURPOSE: This study aimed to evaluate the effectiveness of the laser-assisted new attachment procedure (LANAP) and low-level laser therapy (LLLT) on clinical, biochemical, and radiographic parameters when applied alongside scaling and root planing (SRP). METHODS: The study was designed as a randomized controlled, single-blind, parallel trial involving 68 patients diagnosed with periodontitis. The participants were divided into three groups: Group 1: SRP (control), Group 2: LANAP, and Group 3: LLLT. Clinical measurements, gingival crevicular fluid (GCF) samples, and standard periapical radiographs were obtained pre-treatment and at one- and three-month follow-ups. In GCF, interleukin-1beta (IL-1beta), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) were analyzed. RESULTS: In moderate (4-6 mm) and deep pockets (>/= 7 mm), laser-treated groups showed a significant reduction in pocket depth (PD) and clinical attachment level (CAL) compared to the control group. However, there were no statistically significant differences in biochemical markers between the groups. Group 2 demonstrated significant bone filling compared to the control group. CONCLUSION: In deep pockets, laser-treated groups provide additional benefits to SRP. The application of LLLT positively affected recession (REC). TRIAL REGISTRATION NUMBER: NCT04694222 Date of registration: 01/01/2021.