Evaluation of the effects of using an interdental brush dipped in 0.2% hyaluronic acid gel on clinical periodontal parameters among patients with periodontitis: a randomized controlled trial.

BACKGROUND: The additional use of agents with antibacterial and anti-inflammatory activities, such as hyaluronic acid in treating periodontal disease, has recently become popular. This study aimed to evaluate the effects of using an interdental brush dipped in 0.2% HA gel on clinical periodontal parameters. METHODS: This randomized controlled trial was conducted among 60 patients with stages II/III grades A/B periodontitis. After full-mouth scaling root planning and oral hygiene training, the patients were divided into two groups; the test group was asked to use an interdental brush dipped in 0.2% HA, while the control group was asked to use a regular interdental brush. Clinical periodontal parameters [ gingival index (GI), plaque index (PI), papillary bleeding index (PBI), pocket depth (PD), and clinical attachment loss (CAL) ] were assessed at baseline and in the 1st and 3rd months after treatment. RESULTS: Clinical periodontal parameters were improved in control and test groups at the 1 and 3-month compared to baseline (p < 0.05). The 1st- and 3rd-month PBIs were significantly lower in the test group (p < 0.05). There was no significant difference between the test and control groups regarding PI, PD, GI, and CAL between the follow-up times. CONCLUSIONS: Although the clinical efficacy of the tested methods of interdental brush use was similar, it can be concluded that the use of an interdental brush dipped in HA may contribute to the reduction of gingival bleeding in the early period. CLINICAL SIGNIFICANCE: Incorporating HA into the oral hygiene regime after periodontitis treatment using an interdental brush is a useful and practical method. NAME OF THE REGISTRY: https://clinicaltrials.gov/ TRIAL REGISTRATION NUMBER: NCT06309797. DATE OF REGISTRATION: 07/03/2024 "Retrospectively registered". URL: https://clinicaltrials.gov/study/NCT06309797.