There have been only 24 documented occurrences of the extremely uncommon giant cell tumour of the parotid gland. We report an additional case of a female patient in her late 40s who presented with a 2.5-year history of right-sided face swelling in the preauricular region. Fine-needle aspiration suggested the possibility of a primary giant cell tumour of the parotid, which was confirmed by histopathology, revealing a biphasic population of mononuclear stromal cells and osteoclast-like giant cells. There was no metastatic lesion in the cervical lymph node. No associated carcinomatous component was found. Immunohistochemistry was positive for haematopoietic, monocytic-lineage and mesenchymal markers while it was negative for epithelial and myoepithelial markers.
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