The necessity for prompt identification of Sjogren syndrome in instances of unexplained heart failure: A case report.

RATIONALE: Sjogren's syndrome (SS) is a highly phenotypically diverse autoimmune disorder. It has been reported that 30% to 40% of patients with SS experience systemic complications, including peripheral neuropathies, interstitial lung disease, interstitial nephritis, and lymphoma. To date, SS presenting with heart failure (HF) as the primary manifestation remains exceedingly rare. PATIENT CONCERNS: We report presents a 70-year-old female patient, devoid of any cardiovascular risk factors, who experienced recurrent episodes of HF. DIAGNOSES: During the course of treatment, SS was suspected based on her medical history. This suspicion was subsequently confirmed through elevated serum autoimmune antibody levels and a labial gland biopsy. INTERVENTIONS: The implementation of standard HF management in conjunction with an immunosuppressive regimen. OUTCOMES: At the one-year follow-up, the patient had not been readmitted for HF. LESSONS: This case underscores the critical importance of early identification of HF attributable to SS and highlights the efficacy of combining immunosuppressive therapy with conventional HF treatment as the optimal approach for managing such cases.