Interaction between Saliva, Pellicle, and Dental Erosion.

The dynamic interplay of the oral fluids with the tooth surface is of essential relevance for the modulation of the de- and remineralization of tooth hard substances. It is generally accepted textbook knowledge that the buffering and clearance properties of the saliva are key factors in the prevention of erosive mineral loss. This becomes especially evident when the patients suffer from xerostomia. Furthermore, biomolecules in the oral fluids ensure the formation of the pellicle layer on all solid surfaces. While the enamel pellicle has been shown to diminish erosive attacks to a certain extent, it is unclear if the dentinal pellicle yields the same efficiency. In this context, two aspects seem to be marginalized in research: the dentine surface and the impact of protein adsorption and infiltration in demineralized tooth structures, despite the fact that both are essential for the understanding and modulation of erosive processes. Successful and sustainable prevention strategies are only possible if we understand these dynamic interactions. Therefore, future research should focus on the interaction of proteins with dentine and enamel during repeated de- and remineralization processes.