EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY.

OBJECTIVES: To evaluate the efficacy of Hy-N spray in dry mouth patients. MATERIALS AND METHODS: A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotene. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period. RESULTS: Twenty-nine patients completed the study. After using the Hy-N and Biotene sprays for 1 week, the UWSFR significantly increased from 0.12 +/- 0.16 at baseline to 0.16 +/- 0.18 mL/min postspray usage (P = .04, P </= .01) with moderate improvement. None of the sprays affected salivary pH (P = .72). The mean XQ score also significantly decreased from 34.2 +/- 21.4 at baseline to 23.7 +/- 17.4, 23.1 +/- 15.2, and 26.5 +/- 17.7 after using Hy-N, Biotene, and placebo spray, respectively (P = .001, P = .011, P = .009) with moderate improvement. Biotene was the most preferred saliva substitute spray, followed by Hy-N spray. CONCLUSION: Using the Hy-N and Biotene for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.