2025 Zhonghua jie he he hu xi za z…

[Reversed halo sign as imaging manifestation of primary Sjogren's syndrome with nonspecific interstitial pneumonia].

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Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Vol. 48 (8) : 755-758 • Aug 2025

The reversed halo sign (RHS), also referred to as the atoll sign, represents a distinct imaging finding that was initially characterized in cryptogenic organizing pneumonia and has subsequently been observed in instances of fungal infections, tuberculosis, vasculitis, and tumor pathologies.This case report details the presentation of a patient with primary Sjogren's syndrome and non-specific interstitial pneumonia, who on imaging displayed the RHS-a relatively infrequent finding. Subsequent confirmatory testing, including anti-nuclear antibody panel, lip gland biopsy, and lung biopsy, ultimately confirmed the diagnosis.This case highlights the importance for clinicians considering laboratory investigations and histopathological assessments when imaging results and inconsistent with the clinical picture, aiming to avert misdiagnosis and subsequent mismanagement.

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