Research Papers

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Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response.

Theranostics • 2025 • Vol. 15 (7)

Nasopharyngeal carcinoma (NPC) is a heterogeneous cancer with variable therapeutic responses, highlighting the need to better understand the molecular factors influencing treatment outcomes. This stu…

PMID: 40083932 PICO Pending DOI PMC

Chen, Z; Ji, L; Liu, G

Published: Jan 01, 2025
Navigating the labyrinth: Phenotypes of IgG4-related disease.

Journal of postgraduate medicine • 2025 • Vol. 71 (1)

We report a case of an elderly female with subacute submental neck swelling, dry cough, and a history of significant weight loss. Unexpectedly, a left submandibular chronic sialadenitis was noted on …

PMID: 40085066 PICO Pending DOI PMC

Bajan, K; Samant, R; Shah, M

Published: Jan 01, 2025
Structural brain alterations and changes in resting-state functional connectivity in patients with trigeminal neuralgia: A meta-analysis.

NeuroImage. Clinical • 2025 • Vol. 46

BACKGROUND: Trigeminal neuralgia (TN) is a chronic pain condition characterized by severe, electric shock-like pain in one or more branches of the trigeminal nerve. Even though neuroimaging studies h…

PMID: 40086208 PICO Pending DOI PMC

Caramia, F; Fiorelli, M; Nardoni, L

Published: Jan 01, 2025
Mucoepidermoid Carcinoma Presented as a Lymph Node Metastasis in 9-Year-Old Child: A Case Report.

Annals of clinical and laboratory science • 2025 • Vol. 55 (1)

OBJECTIVE: Salivary gland neoplasms are rare in pediatric and adolescent populations. Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands that most frequently …

PMID: 40089286 PICO Pending DOI

Ahmed, A; Ak, S; Amin, S

Published: Jan 01, 2025
Performance of blood concentrates in controlling inflammatory signs and symptoms after lower third molar extractions: an overview.

Acta cirurgica brasileira • 2025 • Vol. 40

PURPOSE: To summarize the available evidence and answer the following question: What is the current knowledge on the performance of blood concentrates in handling sequelae after lower third molar ext…

PMID: 40105600 PICO Pending DOI PMC

Almeida, V; Costa, M; Lima, L

Published: Jan 01, 2025
Case Report: Camrelizumab plus gemcitabine followed by concurrent chemoradiation for HPV-positive and PD-L1-positive tonsillar squamous cell carcinoma.

Frontiers in immunology • 2025 • Vol. 16

Modality treatment including surgery, chemotherapy, radiation and immunotherapy was considered as standard strategy for tonsillar squamous cell carcinoma (TSCC). We reported a case of a 78-year-old m…

PMID: 40109336 PICO Pending DOI PMC

Li, X; Liu, H; Wang, B

Published: Jan 01, 2025
Dealing With Oral Healthcare Within Broader Healthcare Policy: The Need for Conceptual Before Operational Steps.

HealthcarePapers • 2025 • Vol. 22 (3)

Should oral healthcare be part of Canada's universal healthcare system? If so, how? To effectively deal with oral healthcare within broader healthcare policy, we must first gain clarity on what compr…

PMID: 40116250 PICO Pending DOI

Quinonez, C

Published: Jan 01, 2025
Circulating tumor HPV DNA, antibodies to HPV16 early proteins, and oral HPV16 DNA as biomarkers for HPV-related oropharyngeal cancer screening.

Cancer biomarkers : section A of Disease markers • 2025 • Vol. 42 (1)

BackgroundOropharyngeal cancer rates continue to rise with no effective screening method. Persistent oral oncogenic human papillomavirus (HPV), antibodies to HPV16 early (E) oncoproteins, and circula…

PMID: 40116780 PICO Pending DOI

Alvarez, V; Anderson, K; Chirinos, S

Published: Jan 01, 2025
capital ES, Cyrilliconnection and assessment of the psychological status of orthodontic patients with various types of malocclusion.

Wiadomosci lekarskie (Warsaw, Poland : 1960) • 2025 • Vol. 78 (2)

OBJECTIVE: Aim: Assessment of relationship between the psychological status of orthodontic patients and the type of malocclusion using the Eysenck Personality Questionnaire. PATIENTS AND METHODS: Mat…

PMID: 40125749 PICO Pending DOI

Halych, L; Korobov, P; Kuroiedova, V

Published: Jan 01, 2025
Actual scientific data in comorbid periodontal diseases and heart-vessel pathology.

Wiadomosci lekarskie (Warsaw, Poland : 1960) • 2025 • Vol. 78 (2)

OBJECTIVE: Aim: The aim of this study is to review and analyze contemporary scientific and professional literature to investigate the role of periodontal diseases in the development and progression o…

PMID: 40125766 PICO Pending DOI

Bumbar, Z; Pupin, T; Sichkoriz, K

Published: Jan 01, 2025
Warthin's Tumour Diagnostic Outcome in the Milan System Era and Cytomorphological Pitfalls.

Acta cytologica • 2025 • Vol. 69 (3)

INTRODUCTION: Warthin's tumour (WT) is the second most common salivary gland neoplasm. With classic cytomorphological features of WT, the diagnostic accuracy is over 95%. WT is usually categorized as…

PMID: 40127626 PICO Pending DOI PMC

Kalfert, D; Kholova, I; Lagerstam, H

Published: Jan 01, 2025
Partnering with periodontal patients and care providers to establish research priorities for patient engagement in specialized periodontal care: A study protocol.

PLoS One • 2025 • Vol. 20 (3)

INTRODUCTION: Periodontitis is highly prevalent and disproportionately affects vulnerable populations, including older adults, racial and ethnic minorities, and low-income individuals. While periodon…

PMID: 40131990 PICO Pending DOI PMC

Ball, G; Gibson, M; Lagravere, M

Published: Jan 01, 2025
Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in rats.

Journal of applied oral science : revista FOB • 2025 • Vol. 33

BACKGROUND: Inflammation, oxidative damage, and adenosine triphosphate (ATP) depletion play a role in the pathogenesis of cisplatin (CIS)-induced oral mucositis. OBJECTIVE: The purpose of this resear…

PMID: 40136224 PICO Pending DOI PMC

Alcan Alp, N; Celik, F; Dilber, M

Published: Jan 01, 2025
Oral local factors affecting candida colonization in patients undergoing perioperative oral care.

Journal of microorganism control • 2025 • Vol. 30 (1)

Recently, perioperative oral function management, focusing on oral care, has been considered important from the perspective of preventing infections caused by oral microorganisms. One of the infectio…

PMID: 40139829 PICO Pending DOI

Fujishima, K; Sakuta, T; Tamaki, N

Published: Jan 01, 2025
A Protocol for Void Detection in Root-filled Teeth Using Micro-CT: Ex-vivo.

European endodontic journal • 2025 • Vol. 10 (1)

OBJECTIVE: X-ray microtomography (micro-CT or XMT) has previously been used to measure residual voids in root fillings. However, there is no agreement on a protocol that critically identifies and att…

PMID: 40145482 PICO Pending DOI PMC

Davis, G; Gharib, I; Wong, F

Published: Jan 01, 2025
Evaluation of Apically Extruded Debris During Root Canal Preparation Using ProTaper Ultimate and ProTaper Gold: An Ex Vivo Study.

European endodontic journal • 2025 • Vol. 10 (1)

OBJECTIVE: To assess the extruded debris apically by the ProTaper Ultimate rotary nickel-titanium files compared to the ProTaper Gold files on preparing the mesiobuccal root canals of mandibular mola…

PMID: 40145483 PICO Pending DOI PMC

Alhayki, M; Eid, B; Elemam, R

Published: Jan 01, 2025
Effect of immunonutrition during concurrent chemoradiotherapy on acute oral mucositis in head and neck cancer patients: A prospective randomized study.

PLoS One • 2025 • Vol. 20 (3)

OBJECTIVE: Immunonutrition (IN) supplements, designed to modulate immune system, may help reduce treatment-related toxicities. This study aimed to evaluate the efficacy of IN in reducing acute oral m…

PMID: 40146676 PICO Pending DOI PMC

Chitapanarux, I; Chumachote, A; Kittidachanan, K

Published: Jan 01, 2025
Stabilization of the Dental (Rubber) Dam - Historical Perspectives.

Journal of the history of dentistry • 2025 • Vol. 73 (1)

A brief historical perspective on the creative evolution of dental (rubber) dam stabilization is proffered. While the vast majority of endodontists rely on the application of a metallic or plastic st…

PMID: 40147010 PICO Pending DOI

Gutmann, J; Manjarres, V; Mendez, C

Published: Jan 01, 2025
Evaluation of color stability, wear, and fracture resistance of preformed Bioflx and zirconia crowns: An in vitro study.

Journal of the Indian Society of Pedodontics and Preventive Dentistry • 2025 • Vol. 43 (1)

BACKGROUND: The ideal crowns for primary teeth should be esthetic, durable, and easy to place. Preformed zirconia crowns, although the most commonly used, esthetically pleasing, require significant t…

PMID: 40159617 PICO Pending DOI

Dadpe, M; Dahake, P; Deshmukh, N

Published: Jan 01, 2025
A clinical comparison of the caries inhibitory potential of aluminum gallium arsenide LASER in conjunction with a remineralization paste in non-cavitated carious lesions.

Journal of applied biomaterials & functional materials • 2025 • Vol. 23

BACKGROUND: Dental caries is a progressive disease with varying phases of demineralization and remineralization. If diagnosed before surface cavitation, the scope of reversing the carious lesion is i…

PMID: 40159674 PICO Pending DOI

Hegde, M; Sharma, C

Published: Jan 01, 2025
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