Evidence Gaps Analysis
3688 outcomes from 214 review series
CD010514
Current Version: CD010514.PUB2
Current Evidence Gaps 3 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Coronal caries increment at 24 to 36 months (decayed filled surfaces â DFS) | High | None |
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Periodontitis at 36 months (attachment loss > 0 mm) | Low | Not specified |
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Calculus at 6 months (VolpeâManhold Calculus Index in mm â mean total calculus per participant) | Low | Not specified |
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Plaque at 6 to 7 months (QuigleyâHein Plaque Index) | Moderate | Not specified |
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Gingivitis at 6 to 9 months (LöeâSilness Gingival Index) | Moderate | Not specified |
| adults (children in 2 studies) | triclosan/copolymer/fluoride toothpaste | control toothpaste (no triclosan/copolymer) | Adverse effects | No Evidence Yet | N/A |
CD010526
Current Version: CD010526.PUB3
| 1 older version
Current Evidence Gaps 4 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| patients requiring Class I or Class II resinâbased composite restorations | liner | no liner | Postoperative cold response measurement (CRM) (time it took in seconds for patient to feel cold sensation) Followâup: 1 week | Low | Not specified |
| patients requiring Class I or Class II resinâbased composite restorations | liner | no liner | Restoration failure Followâup: 1 year | Low | Not specified |
| patients requiring Class I or Class II resinâbased composite restorations | liner | no liner | Postoperative hypersensitivity (POH) (Patientâreported Y/N) Followâup: 1 week | Low | Not specified |
| patients requiring Class I or Class II resinâbased composite restorations | liner | no liner | Adverse events | No Evidence Yet | N/A |
Previous Versions
CD010526.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| Patients requiring Class I or Class II resinâbased composite restorations | Liner | No liner | Restoration failure at 1 year | Low | - |
| Patients requiring Class I or Class II resinâbased composite restorations | Liner | No liner | Postoperative hypersensitivity (POH) (Patientâreported Y/N) at 1 week | Low | - |
| Patients requiring Class I or Class II resinâbased composite restorations | Liner | No liner | Postoperative cold response measurement (CRM) at 1 week | Low | - |
| Patients requiring Class I or Class II resinâbased composite restorations | Liner | No liner | Adverse events | No Evidence Yet | - |
CD010535
Current Version: CD010535.PUB2
Current Evidence Gaps 7 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| nursing home residents | oral health education (with information and practical components) | usual care | Gingivitis | Low | Not specified |
| nursing home residents | oral health education (with information and practical components) | usual care | Dental plaque | Low | Not specified |
| nursing home residents | oral health education (with information and practical components) | usual care | Caries/root caries | Low | Not specified |
| nursing home residents | oral health education (with information and practical components) | usual care | Denture plaque | Low | Not specified |
| nursing home residents | oral health education (with information and practical components) | usual care | Denture-induced stomatitis | Low | Not specified |
| nursing home residents | oral health education (with information and practical components) | usual care | Oral health-related quality of life | No Evidence Yet | N/A |
| nursing home residents | oral health education (with information and practical components) | usual care | Oral health | No Evidence Yet | N/A |
CD010572
Current Version: CD010572.PUB2
Current Evidence Gaps 3 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People requiring orthodontic tooth movement | Adjunctive surgical procedures | Conventional treatment | Orthodontic tooth movement in mm (3 months) | Low | Not specified |
| People requiring orthodontic tooth movement | Adjunctive surgical procedures | Conventional treatment | Duration of orthodontic treatment | No Evidence Yet | N/A |
| People requiring orthodontic tooth movement | Adjunctive surgical procedures | Conventional treatment | Harms arising during the course of orthodontic treatment | Very Low | Not specified |
CD010743
Current Version: CD010743.PUB2
Current Evidence Gaps 2 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| children with permanent teeth | fluoride toothpaste containing 10% xylitol | fluoride toothpaste | Caries: increment (DFS) prevented fraction (PF) at 2.5 to 3 years followâup | Low | Not specified |
| children with permanent teeth | fluoride toothpaste containing 10% xylitol | fluoride toothpaste | Adverse effects | No Evidence Yet | N/A |
CD010856
Current Version: CD010856.PUB2
Current Evidence Gaps 11 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Dental fluorosis of aesthetic concern | Low | Not specified |
| People of all ages | Cessation of water fluoridation | Fluoridated water | Disparities in caries by socioeconomic status (SES) | No Evidence Yet | N/A |
| People of all ages | Cessation of water fluoridation | Fluoridated water | Adverse effects | No Evidence Yet | N/A |
| People of all ages | Cessation of water fluoridation | Fluoridated water | Caries in deciduous teeth (dmft/dmfs) | No Evidence Yet | N/A |
| People of all ages | Cessation of water fluoridation | Fluoridated water | Change in proportion of caries-free children (deciduous or permanent teeth) | No Evidence Yet | N/A |
| People of all ages | Cessation of water fluoridation | Fluoridated water | Caries in permanent teeth (DMFS) | Very Low | Not specified |
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Disparities in caries by socioeconomic status (SES) | Very Low | Not specified |
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Caries in deciduous teeth (dmft) | Very Low | Not specified |
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Change in proportion of caries-free children (permanent teeth) | Very Low | Not specified |
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Change in proportion of caries-free children (deciduous teeth) | Very Low | Not specified |
| People of all ages | Initiation of water fluoridation | Low/non-fluoridated water | Caries score in permanent teeth (DMFT) | Very Low | Not specified |
CD010887
Current Version: CD010887.PUB3
| 1 older version
Current Evidence Gaps 21 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Orthodontic tooth movement (OTM) during alignment stage | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Duration of orthodontic treatment | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Total number of orthodontic appliance adjustment appointments during treatment | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Orthodontic tooth movement (OTM) during space closure stage (mm/month) | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Patient perception of pain and discomfort using VAS 0 to 100 mm | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Patientâreported need for analgesics | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | orthodontic appliance treatment with vibrational light forces | conventional orthodontic appliance treatment | Harms and side effects: OIIRR | Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Harms and side effects | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Total number of orthodontic appliance adjustment appointments required during treatment stage | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Orthodontic tooth movement (OTM) during alignment stage | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Patientâreported need for analgesics | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Patientâreported need for analgesics | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Harms and side effects | No Evidence Yet | N/A |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Duration of orthodontic treatment: alignment stage only | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Patient perception of pain and discomfort using VAS 0 to 100 mm | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LED as an adjunctive intervention to conventional orthodontic treatement | conventional orthodontic treatment | Orthodontic tooth movement (OTM) during space closure stage mm/month (canine distalisation) | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Orthodontic tooth movement (OTM) during space closure stage mm/month (maxillary arch) | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Orthodontic tooth movement (OTM) during alignment stage | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Duration of orthodontic treatment during alignment stage only | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Total number of orthodontic appliance adjustment appointments required during treatment: alignment stage only | Very Low | Not specified |
| adolescents and adults with malocclusion undergoing orthodontic treatment | LLLT as an adjunctive intervention to conventional orthodontic treatment | conventional orthodontic treatment | Patient perception of pain and discomfort using VAS 0 to 100 mm | Very Low | Not specified |
Previous Versions
CD010887.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Improvement in occlusion | No Evidence Yet | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Duration of active orthodontic treatment | No Evidence Yet | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Harms: Non-serious adverse effects during treatment | Very Low | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Rate of tooth movement: rate of orthodontic tooth movement in the maxillary arch during space closure in mm/month | Very Low | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Rate of tooth movement: reduction in the Little's irregularity index (LII) during alignment stage due to tooth movement during the first 10 weeks of the alignment stage in mm | Very Low | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Patient-centred outcomes: Pain and discomfort using visual analogue scale (VAS; 0 to 100 mm) | Very Low | - |
| Orthodontic patients with malocclusion | Non-surgical adjunctive interventions | Conventional orthodontic treatment | Harms: Serious adverse effects | Very Low | - |
CD011024
Current Version: CD011024.PUB2
Current Evidence Gaps 24 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | Adverse effects | No Evidence Yet | N/A |
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | Patient satisfaction: measured by questionnaires | No Evidence Yet | N/A |
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | Acceptance of LA | No Evidence Yet | N/A |
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | Completion of dental treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | Successful LA/painless treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | Acceptance of LA | No Evidence Yet | N/A |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | Adverse effects | No Evidence Yet | N/A |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | Patient satisfaction: measured by questionnaires | No Evidence Yet | N/A |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | Successful LA/painless treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | Completion of dental treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | hypnosis | conventional treatment | Successful LA/painless treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | hypnosis | conventional treatment | Completion of dental treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | hypnosis | conventional treatment | Acceptance of LA | No Evidence Yet | N/A |
| children and adolescents having dental treatment | hypnosis | conventional treatment | Patient satisfaction: measured by questionnaires | No Evidence Yet | N/A |
| children and adolescents having dental treatment | hypnosis | conventional treatment | Adverse effects | No Evidence Yet | N/A |
| children and adolescents having dental treatment | the wand | traditional LA | Completion of dental treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | the wand | traditional LA | Acceptance of LA | No Evidence Yet | N/A |
| children and adolescents having dental treatment | the wand | traditional LA | Successful LA/painless treatment | No Evidence Yet | N/A |
| children and adolescents having dental treatment | the wand | traditional LA | Patient satisfaction: measured by questionnaires | No Evidence Yet | N/A |
| children and adolescents having dental treatment | the wand | traditional LA | Adverse effects | No Evidence Yet | N/A |
| children and adolescents having dental treatment | audiovisual distraction | conventional treatment | painârelated behaviour during LA (children who exhibited a negative versus positive behaviour; Frankl Behaviour Rating Scale (FBRS)) | Very Low | Not specified |
| children and adolescents having dental treatment | counterâstimulation or distraction | conventional treatment | pain (Sound, Eyes, and Motor (SEM) scale; dichotomous â any pain versus no pain, higher score indicates high pain experience) | Very Low | Not specified |
| children and adolescents having dental treatment | hypnosis | conventional treatment | pain (Modified Objective Pain Score (mOPS); VAS: 0 to 10, higher score indicates worse pain experience) | Very Low | Not specified |
| children and adolescents having dental treatment | the wand | traditional LA | painârelated behaviour (any disruptive behaviour/sudden reaction/movement) | Very Low | Not specified |
CD011116
Current Version: CD011116.PUB3
| 1 older version
Current Evidence Gaps 26 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Patients undergoing dental treatment | acupressure with thumb, device or sea band | sham acupressure with or without sedation | Presence or absence of gagging | No Evidence Yet | N/A |
| Patients undergoing dental treatment | acupressure with thumb, device or sea band | sham acupressure with or without sedation | Adverse effects | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Acupuncture without sedation | Sham acupuncture | Presence or absence of gagging | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Acupuncture with sedation | Sham acupuncture | Presence or absence of gagging | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Acupuncture with sedation | Sham acupuncture | Adverse effects | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Laser | Control | Adverse effects | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Laser | Control | Completion of dental treatment | No Evidence Yet | N/A |
| Patients undergoing dental treatment | Acupressure with device | Sham acupressure | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with device | Sham acupressure | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with device with sedation | Sham acupressure with sedation | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with device with sedation | Sham acupressure with sedation | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with sea band | Sham acupressure | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with sea band | Sham acupressure | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with sea band with sedation | Sham acupressure with sedation | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with sea band with sedation | Sham acupressure with sedation | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with thumb | Sham acupressure | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with thumb | Sham acupressure | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with thumb with sedation | Sham acupressure with sedation | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupressure with thumb with sedation | Sham acupressure with sedation | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupuncture without sedation | Sham acupuncture | Adverse effects | Very Low | Not specified |
| Patients undergoing dental treatment | Acupuncture without sedation | Sham acupuncture | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupuncture without sedation | Sham acupuncture | Reduction in gagging (patient?reported, dichotomous data) | Very Low | Not specified |
| Patients undergoing dental treatment | Acupuncture with sedation | Sham acupuncture | Completion of dental procedure | Very Low | Not specified |
| Patients undergoing dental treatment | Acupuncture with sedation | Sham acupuncture | Reduction in gagging (patient-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Laser | Control | Reduction in gagging (assessor-reported) | Very Low | Not specified |
| Patients undergoing dental treatment | Laser | Control | Presence or absence of gagging | Very Low | Not specified |
Previous Versions
CD011116.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| people with gagging during dental treatment | acupuncture at P6 point | sham acupuncture | Secondary outcome: adverse events | No Evidence Yet | - |
| people with gagging during dental treatment | acupuncture at P6 point | sham acupuncture | Primary outcome: completion of dental procedure | Very Low | - |
| people with gagging during dental treatment | acupuncture at P6 point | sham acupuncture | Secondary outcome: reduction in gagging: assessor-reported outcome - treatment effectiveness during stage 1 | Very Low | - |
| people with gagging during dental treatment | acupuncture at P6 point | sham acupuncture | Secondary outcome: reduction in gagging: patient-reported outcome | Very Low | - |
CD011131
Current Version: CD011131.PUB2
Current Evidence Gaps 15 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| children with cleft lip | infraorbital nerve block | intravenous analgesia | Time to feeding after surgery | Low | Not specified |
| children with cleft lip | infraorbital nerve block | placebo | Supplemental analgesic requirements (at 4 hours) | Low | Not specified |
| children with cleft lip | infraorbital nerve block | infiltration of the incision | Pain score control | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | intravenous analgesia | Adverse events | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | placebo | Adverse events | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | placebo | Time to feeding after surgery | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | infiltration of the incision | Time to feeding after surgery | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | infiltration of the incision | Adverse events | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | infiltration of the incision | Duration of postoperative analgesia | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | intravenous analgesia | Duration of postoperative analgesia | No Evidence Yet | N/A |
| children with cleft lip | infraorbital nerve block | infiltration of the incision | Supplemental analgesic requirements | Very Low | Not specified |
| children with cleft lip | infraorbital nerve block | placebo | Pain score control (0 to 4 hours) | Very Low | Not specified |
| children with cleft lip | infraorbital nerve block | placebo | Duration of postoperative analgesia | Very Low | Not specified |
| children with cleft lip | infraorbital nerve block | intravenous analgesia | Pain score control (0 to 4 hours) | Very Low | Not specified |
| children with cleft lip | infraorbital nerve block | intravenous analgesia | Supplemental analgesic requirements | Very Low | Not specified |
CD011385
Current Version: CD011385.PUB3
| 1 older version
Current Evidence Gaps 1 gap
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| people with haemophilia or Von Willebrand disease | tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) | placebo or no intervention or usual care with or without placebo | Side effects or other adverse events | Low | Not specified |
| people with haemophilia or Von Willebrand disease | tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) | placebo or no intervention or usual care with or without placebo | Postoperative bleedings requiring intervention | Moderate | Not specified |
Previous Versions
CD011385.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| people with haemophilia or Von Willebrand disease | tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) | placebo or no intervention or usual care with or without placebo | Side effects or other adverse events | Low | - |
| people with haemophilia or Von Willebrand disease | tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) | placebo or no intervention or usual care with or without placebo | Postoperative bleedings requiring intervention | Moderate | - |
CD011423
Current Version: CD011423.PUB2
Current Evidence Gaps 11 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| patients affected by infrabony defects requiring surgical treatment | APC + EMD | EMD | Change in probing depth (PD) (mm) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + EMD | EMD | Change in radiographic bone defect filling (RBF) (%) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + EMD | EMD | Change in clinical attachment level (CAL) (mm) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + GTR | GTR | Change in clinical attachment level (CAL) (mm) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + GTR | GTR | Change in probing depth (PD) (mm) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD | OFD | Change in clinical attachment level (CAL) (mm) (9â12 months followâup) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD | OFD | Change in probing depth (PD) (mm) (9â12 months followâup) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD | OFD | Change in radiographic bone defect filling (RBF) (%) (9â12 months followâup) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD + BG | OFD + BG | Change in probing depth (PD) (mm) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD + BG | OFD + BG | Change in radiographic bone defect filling (RBF) (%) (All followâups) | Very Low | Not specified |
| patients affected by infrabony defects requiring surgical treatment | APC + OFD + BG | OFD + BG | Change in clinical attachment level (CAL) (mm) (All followâups) | Very Low | Not specified |
CD011552
Current Version: CD011552.PUB2
Current Evidence Gaps 12 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (any) | Low | Not specified |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Oral pain on a 0 (no pain) to 10 (maximum pain) scale | Low | Not specified |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (moderate + severe) | Low | Not specified |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Duration of hospitalisation (days) | Low | Not specified |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (severe) | Moderate | Not specified |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (any) | Moderate | Not specified |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (severe) | Moderate | Not specified |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Oral mucositis (moderate + severe) | Moderate | Not specified |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Interruptions to cancer treatment | No Evidence Yet | N/A |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Quality of life | No Evidence Yet | N/A |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Normalcy of diet (days of total parenteral nutrition) | No Evidence Yet | N/A |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Quality of life | No Evidence Yet | N/A |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Duration of hospitalisation (days) | No Evidence Yet | N/A |
| Adults with haematological cancers receiving high-dose melphalan-based treatment prior to haematopoietic stem cell transplantation | Cryotherapy | Control (no treatment or routine care) | Normalcy of diet (days of total parenteral nutrition) | Very Low | Not specified |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Oral pain (1 to 5 scale) | Very Low | Not specified |
| Adults with solid cancers receiving fluorouracil-based cancer treatment | Cryotherapy | Control (no treatment or routine care) | Interruptions to cancer treatment | Very Low | Not specified |
CD011559
Current Version: CD011559.PUB2
Current Evidence Gaps 8 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults at risk of developing osteoradionecrosis of the jaws | Combined HBO and perioperative antibiotics prior to dental implant therapy | Antibiotics alone prior to dental implant therapy | Adverse effects | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | Combined HBO and perioperative antibiotics prior to dental implant therapy | Antibiotics alone prior to dental implant therapy | Incidence of ORN | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | Fluoride gel (450 ppm) | High-content fluoride toothpaste (1350 ppm) | Adverse effects | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | Fluoride gel (450 ppm) | High-content fluoride toothpaste (1350 ppm) | Incidence of ORN | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | HBO following extractions | Perioperative antibiotic prophylaxis â penicillin G following extractions | Adverse effects | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | HBO following extractions | Perioperative antibiotic prophylaxis â penicillin G following extractions | Incidence of ORN | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | PRP in cellulose foam placed in extraction socket | No treatment/placebo â only cellulose foam placed in extraction socket | Incidence of ORN | Very Low | Not specified |
| Adults at risk of developing osteoradionecrosis of the jaws | PRP in cellulose foam placed in extraction socket | No treatment/placebo â only cellulose foam placed in extraction socket | Adverse effects | Very Low | Not specified |
CD011784
Current Version: CD011784.PUB3
| 1 older version
Current Evidence Gaps 2 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| people with oroâantral communication/fistulae | pedicled buccal fat pad flap | buccal flap | Adverse effects of treatment failure (such as graft necrosis and rejection or chronic sinusitis) | No Evidence Yet | N/A |
| people with oroâantral communication/fistulae | pedicled buccal fat pad flap | buccal flap | Successful (complete) closure of oroâantral communication | Very Low | Not specified |
Previous Versions
CD011784.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| people with oroâantral communication/fistulae | pedicled buccal fat pad flap | buccal flap | Adverse effects of treatment failure (such as graft necrosis and rejection or chronic sinusitis) | No Evidence Yet | - |
| people with oroâantral communication/fistulae | pedicled buccal fat pad flap | buccal flap | Successful (complete) closure of oroâantral communication | Very Low | - |
CD011850
Current Version: CD011850.PUB2
Current Evidence Gaps 3 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| pregnant women for preventing dental caries in the primary teeth of their children | fluoride supplementation (tablets) | placebo | Fluorosis (maxillary teeth) at 5 years | Very Low | Not specified |
| pregnant women for preventing dental caries in the primary teeth of their children | fluoride supplementation (tablets) | placebo | Decayed or filled primary tooth surfaces at 3 years | Very Low | Not specified |
| pregnant women for preventing dental caries in the primary teeth of their children | fluoride supplementation (tablets) | placebo | Children with caries in the primary teeth at 3 years | Very Low | Not specified |
CD011930
Current Version: CD011930.PUB3
| 1 older version
Current Evidence Gaps 4 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People with post-extraction bleeding | Interventions for treating post-extraction bleeding | nan | Patient-reported outcomes related to pain or discomfort during the procedure | No Evidence Yet | N/A |
| People with post-extraction bleeding | Interventions for treating post-extraction bleeding | nan | Adverse events | No Evidence Yet | N/A |
| People with post-extraction bleeding | Interventions for treating post-extraction bleeding | nan | Bleeding (amount of blood loss, complete cessation of bleeding, time required for control of bleeding) | No Evidence Yet | N/A |
| People with post-extraction bleeding | Interventions for treating post-extraction bleeding | nan | Treatment-associated average cost | No Evidence Yet | N/A |
Previous Versions
CD011930.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| people with postâextraction bleeding | Interventions for treating postâextraction bleeding | nan | Patientâreported outcomes related to pain or discomfort during the procedure | No Evidence Yet | - |
| people with postâextraction bleeding | Interventions for treating postâextraction bleeding | nan | Treatmentâassociated average cost | No Evidence Yet | - |
| people with postâextraction bleeding | Interventions for treating postâextraction bleeding | nan | Adverse events | No Evidence Yet | - |
| people with postâextraction bleeding | Interventions for treating postâextraction bleeding | nan | Bleeding (amount of blood loss, complete cessation of bleeding, time required for control of bleeding) | No Evidence Yet | - |
CD011990
Current Version: CD011990.PUB2
Current Evidence Gaps 13 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults receiving RT to head and neck with cisplatin/5FU | KGF | Placebo | Oral mucositis (severe) (RT to head and neck with cisplatin/5FU) | High | None |
| Adults receiving BMT/SCT after conditioning for haematological cancers | KGF | Placebo | Oral mucositis (severe) (BMT/SCT after conditioning for haematological cancers) | Low | Not specified |
| Adults receiving BMT/SCT after conditioning for haematological cancers | KGF | Placebo | Oral mucositis (moderate + severe) (BMT/SCT after conditioning for haematological cancers) | Low | Not specified |
| Adults receiving BMT/SCT after conditioning for mixed cancers | GM-CSF | Placebo/no treatment | Oral mucositis (severe) (BMT/SCT after conditioning for mixed cancers) | Low | Not specified |
| Adults receiving CT alone for mixed cancers | KGF | Placebo | Oral mucositis (severe) (CT alone for mixed cancers) | Low | Not specified |
| Adults receiving RT to head and neck | G-CSF | Placebo/no treatment | Oral mucositis (severe) (RT to head and neck) | Low | Not specified |
| Adults receiving CT alone for mixed cancers | KGF | Placebo | Oral mucositis (moderate + severe) (CT alone for mixed cancers) | Moderate | Not specified |
| Adults receiving RT to head and neck with cisplatin/5FU | KGF | Placebo | Oral mucositis (moderate + severe) (RT to head and neck with cisplatin/5FU) | Moderate | Not specified |
| Adults receiving CT alone for mixed cancers | KGF | Placebo | Adverse events | No Evidence Yet | N/A |
| Adults receiving RT to head and neck | G-CSF | Placebo/no treatment | Adverse events | No Evidence Yet | N/A |
| nan | nan | nan | Adverse events | No Evidence Yet | N/A |
| Adults receiving BMT/SCT after conditioning for haematological cancers | GM-CSF | Placebo/no treatment | Oral mucositis (moderate + severe) (BMT/SCT after conditioning for haematological cancers) | Very Low | Not specified |
| Adults receiving CT alone for breast cancer | G-CSF | Placebo/no treatment | Oral mucositis (moderate + severe) (CT alone for breast cancer) | Very Low | Not specified |
| Adults receiving CT alone for mixed cancers | GM-CSF | Placebo/no treatment | Oral mucositis (severe) (CT alone for mixed cancers) | Very Low | Not specified |
| Adults receiving RT to head and neck | GM-CSF | Placebo/no treatment | Oral mucositis (severe) (RT to head and neck) | Very Low | Not specified |
| Adults receiving RT to head and neck | GM-CSF | Placebo/no treatment | Oral mucositis (moderate + severe) (RT to head and neck) | Very Low | Not specified |
CD012018
Current Version: CD012018.PUB2
Current Evidence Gaps 60 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Gingivitis measured by gingival index | Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by proportion of bleeding sites | Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Periodontitis | Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by gingival index | Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Plaque | Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Gingivitis measured by proportion of bleeding sites | Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by proportion of bleeding sites | Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Plaque | Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Gingivitis measured by proportion of bleeding sites | Low | Not specified |
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Harms and adverse effects | No Evidence Yet | N/A |
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Harms and adverse effects | No Evidence Yet | N/A |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by gingival index | No Evidence Yet | N/A |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Harms and adverse outcomes | No Evidence Yet | N/A |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Gingivitis measured by gingival index | No Evidence Yet | N/A |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Periodontitis | No Evidence Yet | N/A |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Interproximal caries | No Evidence Yet | N/A |
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Plaque | Very Low | Not specified |
| adults, 16 years and older | flossing plus toothbrushing | toothbrushing only | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | flossing plus toothbrushing | Plaque | Very Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
| adults, 16 years and older | interdental brushing plus toothbrushing | toothbrushing only | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick | flossing plus toothbrushing | Plaque | Very Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
| adults, 16 years and older | Interdental cleaning stick plus toothbrushing | interdental brushing plus toothbrushing | Plaque | Very Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | toothbrushing only | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | oral irrigation plus toothbrushing | flossing plus toothbrushing | Plaque | Very Low | Not specified |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Gingivitis measured by gingival index | Very Low | Not specified |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
| adults, 16 years and older | rubber/elastomeric cleaning stick plus toothbrushing | toothbrushing only | Plaque | Very Low | Not specified |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Plaque | Very Low | Not specified |
| adults, 16 years and older | wooden cleaning stick plus toothbrushing | flossing plus toothbrushing | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Plaque | Very Low | Not specified |
| adults, 16 years and older | wooden interdental cleaning stick plus toothbrushing | toothbrushing only | Gingivitis measured by proportion of bleeding sites | Very Low | Not specified |
CD012155
Current Version: CD012155.PUB3
| 1 older version
Current Evidence Gaps 23 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored homeâbased peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | Caries presence in primary teeth (children assessed at 5â6 yrs) | Low | Not specified |
| For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored homeâbased peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | dmft (children assessed at 5â6 yrs) | Low | Not specified |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | dmft (children assessed at 5 yrs) | Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottleâfeeding and sleep), for infants and young children | Standard care | dmfs (children assessed at 1â3 yrs) | Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers, infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | dmfs (children assessed at 3 yrs) | Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers, infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | dmft (children assessed at 6 yrs) | Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottleâfeeding and sleep), for infants and young children | Standard care | Caries presence in primary teeth (children assessed at 3â5 yrs) | Moderate | Not specified |
| For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored homeâbased peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures (including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children) and clinical measures for mothers (basic restorative treatment and preventive (1 trial included CHX varnish application)) | Standard care | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Prophylaxis (teeth cleaning) and CHX or iodineâNaF solution application in dentition of women | Placebo | dmft | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Prophylaxis (teeth cleaning) and CHX or iodineâNaF solution application in dentition of women | Placebo | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | A daily dose of 2400 IU vitamin D3 supplementation or matching placebo tablets from pregnancy week 24 to 1âweek postpartum. In addition, all women were instructed to continue supplementation of 400 IU of vitamin D3 during pregnancy as recommended in national pregnancy guidelines for women. | Vitamin D supplementation as recommended in the pregnancy guidelines | dmft | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | A daily dose of 2400 IU vitamin D3 supplementation or matching placebo tablets from pregnancy week 24 to 1âweek postpartum. In addition, all women were instructed to continue supplementation of 400 IU of vitamin D3 during pregnancy as recommended in national pregnancy guidelines for women. | Vitamin D supplementation as recommended in the pregnancy guidelines | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | dmft | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | dmfs | No Evidence Yet | N/A |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | Caries presence in primary teeth (children assessed at 4 yrs) | Very Low | Not specified |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures (including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children) and clinical measures for mothers (basic restorative treatment and preventive (1 trial included CHX varnish application)) | Standard care | Caries presence in primary teeth (children assessed at 18â24 months) | Very Low | Not specified |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures (including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children) and clinical measures for mothers (basic restorative treatment and preventive (1 trial included CHX varnish application)) | Standard care | dmft (children assessed at 18 months) | Very Low | Not specified |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age | Prophylaxis (teeth cleaning) and CHX or iodineâNaF solution application in dentition of women | Placebo | Caries presence in primary teeth (children assessed at 2â3 yrs) | Very Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | A daily dose of 2400 IU vitamin D3 supplementation or matching placebo tablets from pregnancy week 24 to 1âweek postpartum. In addition, all women were instructed to continue supplementation of 400 IU of vitamin D3 during pregnancy as recommended in national pregnancy guidelines for women. | Vitamin D supplementation as recommended in the pregnancy guidelines | Caries presence in primary teeth (children assessed at 6 yrs) | Very Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottleâfeeding and sleep), for infants and young children | Standard care | dmft (children assessed at 4 yrs) | Very Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | Caries presence in primary teeth (children assessed at 3 yrs) | Very Low | Not specified |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers, infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | Caries presence in primary teeth (children assessed at 1â6 yrs) | Very Low | Not specified |
Previous Versions
CD012155.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| For interventions, pregnant and lactating women; for outcomes, young children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored home-based peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | dmft index score (range 0 to 20, children assessed at 4 yrs) | Low | - |
| For interventions, pregnant and lactating women; for outcomes, young children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored home-based peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | Caries presence in primary teeth (children 0 to 6 yrs) | Low | - |
| For interventions, pregnant women and mothers of infants in the first year of life for the intervention; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | dmft index score (range 0 to 20, children assessed at 4 yrs) | Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Diet and feeding practice advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottle feeding and sleep), for infants and young children | Standard care | dmfs index score (range 0 to 80, children 0 to 6 yrs) | Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | Caries presence in primary teeth (children 0 to 6 yrs) | Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Diet and feeding practice advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottle feeding and sleep), for infants and young children | Standard care | Caries presence in primary teeth (children 0 to 6 yrs) | Moderate | - |
| For interventions, pregnant and lactating women; for outcomes, young children up to 6 years of age | Breastfeeding promotion and support (e.g. individual tailored home-based peer counselling focused on providing information about the importance of breastfeeding and offering advice and support for healthy breastfeeding) | Standard care | dmfs index score (range 0 to 80, children 0 to 6 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age for outcome | Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in dentition of women | Placebo | dmfs index score (range 0 to 80, children 0 to 6 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age for outcome | Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in dentition of women | Placebo | dmft index score (range 0 to 20, children assessed at 4 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers of infants in the first year of life for the intervention; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | dmfs index score (range 0 to 80, children 0 to 6 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | dmfs index score (range 0 to 80, children 0 to 6 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | dmft index score (range 0 to 20, children assessed at 4 yrs) | No Evidence Yet | - |
| For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age for outcome | Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in dentition of women | Placebo | Caries presence in primary teeth (children 0 to 6 yrs) | Very Low | - |
| For interventions, pregnant women and mothers of infants in the first year of life for the intervention; for outcomes, children up to 6 years of age | Consumption of xylitol chewing gum by women | Consumption of CHX/xylitol gum by women or CHX varnish applied to women's dentition | Caries presence in primary teeth (children 0 to 6 yrs) | Very Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Advice about how to achieve a healthy diet for their infants (tailored advice focused on ensuring a diet low in saturated fat and cholesterol intake) | Standard care | Caries presence in primary teeth (children 0 to 6 yrs) | Very Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Diet and feeding practice advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to use of bottle feeding and sleep), for infants and young children | Standard care | dmft index score (range 0 to 20, children assessed at 4 yrs) | Very Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | dmft index score (range 0 to 20, children assessed at 4 yrs) | Very Low | - |
| For interventions, pregnant women and mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years of age | Package of oral health education and promotion measures including oral hygiene advice for pregnant women, mothers infants and young children, and dietary and feeding practice advice focused on infants and young children | Standard care | dmfs index score (range 0 to 80, children 0 to 6 yrs) | Very Low | - |
Showing 181 to 200 of 214 review series
Summary Statistics
214
Review Series
3688
PICO Questions
Evidence Certainty
High
(%)
Moderate
(%)
Low
(%)
Very Low
(%)
No Evidence Yet
(%)
GRADE Downgrading Reasons
Risk of Bias
985
(85.8%)
Imprecision
895
(78.0%)
Inconsistency
253
(22.0%)
Indirectness
188
(16.4%)
Publication Bias
48
(4.2%)