Evidence Gaps Analysis
3688 outcomes from 214 review series
CD009197
Current Version: CD009197.PUB5
| 3 older versions
Current Evidence Gaps 6 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | All CVDârelated death | No Evidence Yet | N/A |
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | Allâcause death | No Evidence Yet | N/A |
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | All cardiovascular events | Very Low | Not specified |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | Allâcause death | Very Low | Not specified |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | All CVDârelated death | Very Low | Not specified |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | All cardiovascular events | Very Low | Not specified |
Previous Versions
CD009197.PUB4
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | All CVDârelated death | No Evidence Yet | - |
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | Allâcause death | No Evidence Yet | - |
| people with cardiovascular disease and chronic periodontitis | periodontal treatment â scaling and root planing (SRP) plus advice | community care â advice only | All cardiovascular events | Very Low | - |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | Allâcause death | Very Low | - |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | All cardiovascular events | Very Low | - |
| people with periodontitis and metabolic syndrome | scaling and root planing (SRP) plus antibiotics | supragingival scaling | All CVDârelated death | Very Low | - |
CD009197.PUB3
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| patients with cardiovascular disease and chronic periodontitis | periodontal treatment | community care | All-cause and CVD-related death | No Evidence Yet | - |
| patients with cardiovascular disease and chronic periodontitis | periodontal treatment | community care | All cardiovascular events | Very Low | - |
CD009197.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| patients with cardiovascular disease and chronic periodontitis | periodontal treatment | community care | All-cause and CVD-related death | No Evidence Yet | - |
| patients with cardiovascular disease and chronic periodontitis | periodontal treatment | community care | All cardiovascular events | Very Low | - |
CD009376
Current Version: CD009376.PUB2
Current Evidence Gaps 15 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults treated for periodontitis and receiving supportive periodontal therapy | Minocycline or doxycycline gel plus mechanical debridement | Mechanical debridement | Clinical attachment level (mm) | Low | Not specified |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Minocycline or doxycycline gel plus mechanical debridement | Mechanical debridement | Pocket depth (mm) | Low | Not specified |
| Adults treated for periodontitis and receiving SPT | SPT performed by general dental practitioners under specialist prescription | SPT performed in a specialist practice | Adverse events | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving SPT | SPT performed by general dental practitioners under specialist prescription | SPT performed in a specialist practice | Clinical attachment loss | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving SPT | SPT performed by general dental practitioners under specialist prescription | SPT performed in a specialist practice | Tooth loss | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Minocycline or doxycycline gel plus mechanical debridement | Mechanical debridement | Adverse events | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Minocycline or doxycycline gel plus mechanical debridement | Mechanical debridement | Tooth loss | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Photodynamic therapy plus mechanical debridement | Mechanical debridement | Tooth loss | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Photodynamic therapy plus mechanical debridement | Mechanical debridement | Adverse events | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Photodynamic therapy plus mechanical debridement | Mechanical debridement | Bleeding on probing | No Evidence Yet | N/A |
| Adults treated for periodontitis and receiving SPT | SPT performed by general dental practitioners under specialist prescription | SPT performed in a specialist practice | Bleeding on probing (%) | Very Low | Not specified |
| Adults treated for periodontitis and receiving SPT | SPT performed by general dental practitioners under specialist prescription | SPT performed in a specialist practice | Probing pocket depth (mm) | Very Low | Not specified |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Minocycline or doxycycline gel plus mechanical debridement | Mechanical debridement | Bleeding on probing (ratios) | Very Low | Not specified |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Photodynamic therapy plus mechanical debridement | Mechanical debridement | Probing pocket depth (mm) | Very Low | Not specified |
| Adults treated for periodontitis and receiving supportive periodontal therapy | Photodynamic therapy plus mechanical debridement | Mechanical debridement | Clinical attachment level (mm) | Very Low | Not specified |
CD009378
Current Version: CD009378.PUB2
Current Evidence Gaps 2 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Children aged 4 to 12 years | Behavioural intervention (both oral hygiene and dietary components) | No intervention or delayed intervention | Caries - DMFS (prevented fraction (PF)) | Low | Not specified |
| Children aged 4 to 12 years | Behavioural intervention (both oral hygiene and dietary components) | No intervention or delayed intervention | Plaque indices | Low | Not specified |
CD009409
Current Version: CD009409.PUB2
Current Evidence Gaps 13 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People diagnosed with periodontitis | Periodontal treatment | No treatment | Shortâterm change of DBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis | Periodontal treatment | No treatment | Longâterm change of SBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis | Periodontal treatment | No treatment | Shortâterm change of SBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis | Periodontal treatment | No treatment | Longâterm change of DBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis | Periodontal treatment | No treatment | Longâterm change of DBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis and other cardiovascular diseases except hypertension | Periodontal treatment | No treatment | Longâterm change of DBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis and other cardiovascular diseases except hypertension | Periodontal treatment | No treatment | Longâterm change of SBP (mmHg) | Low | Not specified |
| People diagnosed with periodontitis, or hypertension, or both | Periodontal treatment | Supraâgingival scaling | Shortâterm change of DBP (mmHg) â people diagnosed with periodontitis | Low | Not specified |
| People diagnosed with periodontitis and hypertension | Periodontal treatment | Supraâgingival scaling | Shortâterm change of SBP (mmHg) | Moderate | Not specified |
| People diagnosed with periodontitis and hypertension | Periodontal treatment | Supraâgingival scaling | Shortâterm change of DBP (mmHg) | Moderate | Not specified |
| People diagnosed with periodontitis, or hypertension, or both | Periodontal treatment | Supraâgingival scaling | nan | Moderate | Not specified |
| People diagnosed with periodontitis and other cardiovascular diseases except hypertension | Periodontal treatment | No treatment | Shortâterm change of SBP (mmHg) | Very Low | Not specified |
| People diagnosed with periodontitis and other cardiovascular diseases except hypertension | Periodontal treatment | No treatment | Shortâterm change of DBP (mmHg) | Very Low | Not specified |
| People diagnosed with periodontitis, or hypertension, or both | Periodontal treatment | Supraâgingival scaling | Longâterm change of SBP (mmHg) â people diagnosed with periodontitis | Very Low | Not specified |
| People diagnosed with periodontitis, or hypertension, or both | Periodontal treatment | Supraâgingival scaling | Shortâterm change of SBP (mmHg) â people diagnosed with periodontitis | Very Low | Not specified |
| People diagnosed with periodontitis, or hypertension, or both | Periodontal treatment | Supraâgingival scaling | Longâterm change of DBP (mmHg) â people diagnosed with periodontitis | Very Low | Not specified |
CD009434
Current Version: CD009434.PUB2
Current Evidence Gaps 10 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through tactile stimuli - short term (0 to 24 hours) | Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Adverse events | Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through air blast stimuli - short term (0 to 24 hours) | Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Adverse events | Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Patient-reported quality of life | No Evidence Yet | N/A |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Patient-reported quality of life | No Evidence Yet | N/A |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through tactile stimuli - long term (more than 2 months) | Very Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through air blast stimuli - long term (more than 2 months) | Very Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through tactile stimuli - medium term (24 hours to 2 months) | Very Low | Not specified |
| patients with dentinal hypersensitivity | laser | placebo/no treatment | Changes in intensity of pain (VAS) when tested through air blast stimuli - medium term (24 hours to 2 months) | Very Low | Not specified |
CD009603
Current Version: CD009603.PUB3
| 1 older version
Current Evidence Gaps 7 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Stimulated whole saliva (end of treatment) | Low | Not specified |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Mouth dryness (at the end of treatment 4â6 weeks) | Low | Not specified |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Unstimulated whole saliva (end of treatment) | Low | Not specified |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Unstimulated whole saliva (1 year followâup) | Low | Not specified |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Stimulated whole saliva (1 year followâup) | Low | Not specified |
| People with dry mouth due to Sjögren's Syndrome | Electrostimulation | Placebo | Stimulated whole saliva (end of treatment) | Very Low | Not specified |
| People with dry mouth due to Sjögren's Syndrome | Electrostimulation | Placebo | Unstimulated whole saliva (end of treatment) | Very Low | Not specified |
Previous Versions
CD009603.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Unstimulated whole saliva (1 year followâup) | Low | - |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Stimulated whole saliva (1 year followâup) | Low | - |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Mouth dryness (at the end of treatment 4â6 weeks) | Low | - |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Unstimulated whole saliva (end of treatment) | Low | - |
| People with dry mouth due to either radiotherapy or Sjögren's Syndrome | Acupuncture | Placebo (sham acupuncture) | Stimulated whole saliva (end of treatment) | Low | - |
| People with dry mouth due to Sjögren's Syndrome | Electrostimulation | Placebo | Unstimulated whole saliva (end of treatment) | Very Low | - |
| People with dry mouth due to Sjögren's Syndrome | Electrostimulation | Placebo | Stimulated whole saliva (end of treatment) | Very Low | - |
CD009606
Current Version: CD009606.PUB2
Current Evidence Gaps 3 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| adults (18 years of age or older) with prosthodontic restorations | metal-free materials | metal-ceramic or other conventional all-metal materials | failure of the prosthesis | Very Low | Not specified |
| adults (18 years of age or older) with prosthodontic restorations | metal-free materials | metal-ceramic or other conventional all-metal materials | complications | Very Low | Not specified |
| adults (18 years of age or older) with prosthodontic restorations | metal-free materials | metal-ceramic or other conventional all-metal materials | aesthetic evaluation | Very Low | Not specified |
CD009742
Current Version: CD009742.PUB2
Current Evidence Gaps 12 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA, intraligamental LA | No treatment | Physiological parameters | No Evidence Yet | N/A |
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA, intraligamental LA | No treatment | Bleeding | No Evidence Yet | N/A |
| Children undergoing dental extractions under general anaesthetic | Intraligamental injection LA | No treatment | Bleeding | No Evidence Yet | N/A |
| Children undergoing dental extractions under general anaesthetic | Intraligamental injection LA | No treatment | Physiological parameters | No Evidence Yet | N/A |
| Children undergoing dental extractions under general anaesthetic | Topical LA | Placebo or no treatment | Physiological parameters | No Evidence Yet | N/A |
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA | Placebo or no treatment | Bleeding | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA | Placebo or no treatment | Physiological parameters | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA | Placebo or no treatment | Pain or distress | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Infiltration injection LA, intraligamental LA | No treatment | Pain or distress | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Intraligamental injection LA | No treatment | Pain | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Topical LA | Placebo or no treatment | Bleeding | Very Low | Not specified |
| Children undergoing dental extractions under general anaesthetic | Topical LA | Placebo or no treatment | Pain or distress | Very Low | Not specified |
CD009853
Current Version: CD009853.PUB2
Current Evidence Gaps 9 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Measures of health service utilisation: mean number of visits per 0- to 15-year-old | Low | Not specified |
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Patient outcomes: mean percentage of 0- to 15-year-olds having one or more teeth extracted | Low | Not specified |
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Patient outcomes: mean number of decayed teeth per 14- to 15-year-old (data for 0- to 15-year-olds NR) | Low | Not specified |
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Measures of clinical activity: mean percentage of 0- to 15-year-olds receiving active preventive advice | Low | Not specified |
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Healthcare costs: mean expenditure in GBP (currency year NR) per 0- to 15-year-old | Low | Not specified |
| Children undergoing routine continuing dental care at 354 dental practices | Capitation remuneration | Fee-for-service remuneration | Patient outcomes: mean number of filled teeth per 0- to 15-year-old | Low | Not specified |
| Dentists seeing children with erupted second permanent molars | Fee-for-service remuneration | No specific intervention | Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) â adjusted | Very Low | Not specified |
| Dentists seeing children with erupted second permanent molars | Fee-for-service remuneration | No specific intervention | Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) â unadjusted | Very Low | Not specified |
| Dentists seeing children with erupted second permanent molars | Fee-for-service remuneration | No specific intervention | Healthcare costs: cost-effectiveness of fee-for-service vs. control (reported as the "% change in outcome per £[GBP]" â currency year NR) | Very Low | Not specified |
CD009857
Current Version: CD009857.PUB2
Current Evidence Gaps 14 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Gingivitis | Low | Not specified |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Plaque | Low | Not specified |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Quality of life | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Periodontitis | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Interproximal caries | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Harms and adverse outcomes | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Bad breath (halitosis) | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Interproximal caries | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Harms and adverse outcomes | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Bad breath (halitosis) | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Quality of life | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Flossing plus toothbrushing | Periodontitis | No Evidence Yet | N/A |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Gingivitis | Very Low | Not specified |
| Adults 16 years and older | Interdental brushing plus toothbrushing | Toothbrushing alone | Plaque | Very Low | Not specified |
CD009858
Current Version: CD009858.PUB3
| 1 older version
Current Evidence Gaps 5 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| dental patients requiring restorative treatment | rubber dam | cotton rolls | Survival rate of restorations (6 months) | Low | Not specified |
| dental patients requiring restorative treatment | rubber dam | cotton rolls | Adverse events | No Evidence Yet | N/A |
| dental patients requiring restorative treatment | rubber dam | cotton rolls | Survival rate of restorations (24 months) | Very Low | Not specified |
| dental patients requiring restorative treatment | rubber dam | cotton rolls | Survival rate of restorations (12 months) | Very Low | Not specified |
| dental patients requiring restorative treatment | rubber dam | cotton rolls | Survival rate of restorations (18 months) | Very Low | Not specified |
Previous Versions
CD009858.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| dental patients | rubber dam | cotton rolls | Survival rate (6 months) | Very Low | - |
| dental patients | rubber dam | cotton rolls | Survival rate (24 months) | Very Low | - |
CD010136
Current Version: CD010136.PUB4
| 2 older versions
Current Evidence Gaps 14 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Pain at 24 hours | Low | Not specified |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Pain at 72 hours | Low | Not specified |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Pain at 7 days | Low | Not specified |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Adverse effects | Low | Not specified |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Swelling at 7 days | Low | Not specified |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Swelling at 24 hours | No Evidence Yet | N/A |
| Adults with symptomatic apical periodontitis | Single dose of systemic antibiotics (clindamycin) with total chemo-mechanical debridement and root filling | Matched placebo with total chemo-mechanical debridement and root filling | Swelling at 72 hours | No Evidence Yet | N/A |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Swelling at 7 days | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Pain at 7 days | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Pain at 72 hours | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Pain at 24 hours | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Adverse effects | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Swelling at 24 hours | Very Low | Not specified |
| Adults with symptomatic necrotic tooth or localised acute apical abscess | 7 days of postoperative systemic antibiotics (phenoxymethylpenicillin) with partial or total chemo-mechanical debridement and analgesics | Matched placebo with partial or total chemo-mechanical debridement and analgesics | Swelling at 72 hours | Very Low | Not specified |
Previous Versions
CD010136.PUB3
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Adverse effects | No Evidence Yet | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 72 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 72 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 48 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 24 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 48 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 24 hours | Very Low | - |
CD010136.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Adverse effects | No Evidence Yet | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 48 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 72 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 48 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 72 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Swelling at 24 hours | Very Low | - |
| adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement) | systemic antibiotics, partial or total pulpectomy and analgesics | matched placebo, partial or total pulpectomy and analgesics | Pain at 24 hours | Very Low | - |
CD010173
Current Version: CD010173.PUB3
| 1 older version
Current Evidence Gaps 3 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| OSCC or OPMD symptomâfree individuals screened opportunistically or through an organised screening programme | Conventional oral examination/visual inspection | nan | OSCC or OPMD | Low | Not specified |
| OSCC or OPMD symptomâfree individuals with tobacco habits | Conventional oral examination plus vital rinsing (toluidine blue) | Conventional oral examination alone | Oral cancer as indicated by the National Cancer Registry | Moderate | Not specified |
| OSCC or OPMD symptomâfree individuals screened through an organised screening programme | Mouth selfâexamination | nan | OSCC or OPMD | Very Low | Not specified |
| OSCC or OPMD symptomâfree individuals screened through an organised screening programme | Remote screening of the oral cavity | nan | OSCC or OPMD | Very Low | Not specified |
Previous Versions
CD010173.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| nan | nan | nan | nan | No Evidence Yet | - |
| nan | nan | nan | nan | No Evidence Yet | - |
| nan | nan | nan | nan | No Evidence Yet | - |
| nan | nan | nan | nan | No Evidence Yet | - |
| nan | nan | nan | nan | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened opportunistically, or through an organised screening programme (Individuals attending for opportunistic screening (2), organised screening programme (4), validation as part of an organised screening programme or randomised controlled trial (3), screening as part of a routine surveillance appointment (1)) | Conventional oral examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened opportunistically, or through an organised screening programme (Individuals attending for opportunistic screening (2), organised screening programme (4), validation as part of an organised screening programme or randomised controlled trial (3), screening as part of a routine surveillance appointment (1)) | Conventional oral examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened opportunistically, or through an organised screening programme (Individuals attending for opportunistic screening (2), organised screening programme (4), validation as part of an organised screening programme or randomised controlled trial (3), screening as part of a routine surveillance appointment (1)) | Conventional oral examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened opportunistically, or through an organised screening programme (Individuals attending for opportunistic screening (2), organised screening programme (4), validation as part of an organised screening programme or randomised controlled trial (3), screening as part of a routine surveillance appointment (1)) | Conventional oral examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened through an organised screening programme ( Individuals attending for organised screening programme (2)) | Mouth self examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened through an organised screening programme ( Individuals attending for organised screening programme (2)) | Mouth self examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened through an organised screening programme ( Individuals attending for organised screening programme (2)) | Mouth self examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals screened through an organised screening programme ( Individuals attending for organised screening programme (2)) | Mouth self examination | No comparison | Oral cavity cancer or potentially malignant disorder | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals with tobacco habits (Individuals attending an organised screening programme) | Conventional oral examination plus vital rinsing (Toluidine blue) | Conventional oral examination alone | Detection of oral preâmalignant lesions and malignant lesions | No Evidence Yet | - |
| Oral cavity cancer or potentially malignant disorder symptomâfree individuals with tobacco habits (Individuals attending an organised screening programme) | Conventional oral examination plus vital rinsing (Toluidine blue) | Conventional oral examination alone | Incidence of oral cancer | No Evidence Yet | - |
CD010176
Current Version: CD010176.PUB3
| 1 older version
Current Evidence Gaps 42 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Complications | Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Complications | Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Complications | Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Implant failure rate | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Need for additional augmentation prior to implant placement | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Implant failure rate | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Implant failure rate | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Need for additional augmentation prior to implant placement | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Need for additional augmentation prior to implant placement | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Implant failure rate | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Changes in width of alveolar ridge (mm) | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Implant failure rate | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Need for additional augmentation prior to implant placement | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | N/A |
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts | Xenografts | Need for additional augmentation prior to implant placement | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Allografts with synthetic cell-binding peptide P-15 | Allografts without synthetic cell-binding peptide P-15 | Complications | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Implant failure rate | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts | Xenografts | Need for additional augmentation prior to implant placement | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts single particle size | Alloplasts multiple particle size | Complications | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alloplasts with membrane | Alloplasts without membrane | Complications | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Complications | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (alloplasts)) | Extraction | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Changes in width of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Need for additional augmentation prior to implant placement | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Changes in height of alveolar ridge (mm) | Very Low | Not specified |
| Adults requiring replacement of missing teeth | Alveolar ridge preservation (ARP) techniques (bone grafting (xenografts)) | Extraction | Implant failure rate | Very Low | Not specified |
Previous Versions
CD010176.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| People requiring replacement of missing teeth | Allograft | Extraction | Changes in width of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Changes in height of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Changes in height of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Changes in width of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Implant failures at 12 months | Low | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Changes in height of alveolar ridge at 12 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Changes in probing pocket depth at teeth adjacent to the extraction site at 12 months (mm) | Low | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Changes in width of alveolar ridge at 9 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Changes in height of alveolar ridge at 9 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Changes in width of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Changes in height of alveolar ridge at 6 month follow-up (mm) | Low | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Peri-implant marginal bone level changes at 7 months | Low | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Implant failures at 7-36 months | Low | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Need for additional augmentation prior to implant placement at 7-36 months | Low | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Changes in width of alveolar ridge at 6-12 month follow-up (mm) | Moderate | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Changes in width of alveolar ridge at 6-36 month follow-up (mm) | Moderate | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Changes in height of alveolar ridge at 6-36 month follow-up (mm) | Moderate | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Changes in probing depth at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft | Extraction | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Need for additional augmentation prior to implant placement | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Peri-implant marginal bone level changes | No Evidence Yet | - |
| People requiring replacement of missing teeth | Allograft with synthetic cell-binding peptide P-15 | Allograft without synthetic cell-binding peptide P-15 | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Need for additional augmentation prior to implant placement | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Peri-implant marginal bone level changes | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast | Xenograft | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Peri-implant marginal bone level changes | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Need for additional augmentation prior to implant placement | No Evidence Yet | - |
| People requiring replacement of missing teeth | Alloplast with membrane | Alloplast without membrane | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Peri-implant marginal bone level changes | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Need for additional augmentation prior to implant placement | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | DBM single particles | DBM multiple particles | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Prosthodontic outcomes of rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Complications (e.g. discomfort pain and swelling) | No Evidence Yet | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Aesthetic outcomes of future prosthodontic rehabilitation | No Evidence Yet | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Changes in probing depth at teeth adjacent to the extraction site | No Evidence Yet | - |
| People requiring replacement of missing teeth | Xenograft | Extraction | Changes in clinical attachment level (CAL) at teeth adjacent to the extraction site | No Evidence Yet | - |
CD010229
Current Version: CD010229.PUB2
Current Evidence Gaps 7 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Caries removal | Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Need for anaesthesia - children | Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Pain - 6-face rating scale (moderate and high pain) | Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Pulpal inflammation or necrosis - 6 months follow-up | Very Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Marginal integrity of restorations - 6 months follow-up | Very Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Pulpal inflammation or necrosis - 1 week follow-up | Very Low | Not specified |
| people with caries in deciduous and permanent teeth | laser for caries removal | standard drill for caries removal | Durability of restoration - 6 months follow-up | Very Low | Not specified |
CD010263
Current Version: CD010263.PUB2
Current Evidence Gaps 12 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| adolescents and adults undergoing orthodontic treatment | low-level laser therapy | placebo | Patient-reported pain intensity or pain relief (VAS 1-100mm) - 24 hours | Low | Not specified |
| adolescents and adults undergoing orthodontic treatment | low-level laser therapy | placebo | Adverse effects | No Evidence Yet | N/A |
| adolescents and adults undergoing orthodontic treatment | vibratory stimulation | no intervention or placebo vibration | Adverse effects | No Evidence Yet | N/A |
| adolescents undergoing orthodontic treatment | chewing gum or wafer | placebo or no chewing gum | Adverse effects | No Evidence Yet | N/A |
| adults undergoing orthodontic treatment | brain wave music (BWM) | no special instructions | Adverse effects for BWM | No Evidence Yet | N/A |
| adults undergoing orthodontic treatment | cognitive behavioural therapy (CBT) | no special instructions | Adverse effects for CBT | No Evidence Yet | N/A |
| people undergoing orthodontic treatment | text message | no text message | Adverse effects | No Evidence Yet | N/A |
| adolescents and adults undergoing orthodontic treatment | vibratory stimulation | no intervention or placebo vibration | Patient-reported pain intensity or pain relief (VAS 1-100mm) - 24 hours | Very Low | Not specified |
| adolescents undergoing orthodontic treatment | chewing gum or wafer | placebo or no chewing gum | Patient-reported pain intensity or pain relief (VAS upon chewing 1-100mm) - 24 hours | Very Low | Not specified |
| adults undergoing orthodontic treatment | brain wave music (BWM) | no special instructions | Patient-reported pain intensity or pain relief (VAS 1-100mm) - 24 hours | Very Low | Not specified |
| adults undergoing orthodontic treatment | cognitive behavioural therapy (CBT) | no special instructions | Patient-reported pain intensity or pain relief (VAS 1-100mm) - 24 hours | Very Low | Not specified |
| people undergoing orthodontic treatment | text message | no text message | Patient-reported pain intensity or pain relief (VAS 1-100mm) - 24 hours | Very Low | Not specified |
CD010341
Current Version: CD010341.PUB2
Current Evidence Gaps 11 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| People with oral cavity or oropharyngeal cancers | EGFR mAb (either cetuximab or nimotuzumab + either RT or CRT) | RT or CRT alone | Overall survival | Moderate | Not specified |
| People with oral cavity or oropharyngeal cancers | EGFR mAb (either cetuximab or nimotuzumab + either RT or CRT) | RT or CRT alone | Locoregional control | Moderate | Not specified |
| People with oral cavity or oropharyngeal cancers | EGFR mAb (either cetuximab or nimotuzumab + either RT or CRT) | RT or CRT alone | Adverse effects (skin toxicity/acneiform rash - grades ⥠3) | No Evidence Yet | N/A |
| People with oral cavity or oropharyngeal cancers | EGFR mAb (either cetuximab or nimotuzumab + either RT or CRT) | RT or CRT alone | Adverse effects (skin toxicity/acneiform rash - all grades) | No Evidence Yet | N/A |
| People with oral cavity or oropharyngeal cancers | EGFR mAb (either cetuximab or nimotuzumab + either RT or CRT) | RT or CRT alone | Progression-free survival | No Evidence Yet | N/A |
| People with oral cavity or oropharyngeal cancers | Recombinant Interleukin (rIL-2) + standard therapy (surgery) | Standard therapy (surgery) alone | Adverse effects | No Evidence Yet | N/A |
| People with oral cavity or oropharyngeal cancers | Tyrosine kinase inhibitors (erlotinib gefitinib or lapatinib) + standard therapy (either RT or CRT) | Standard therapy (either RT or CRT alone) | Adverse effects (gastrointestinal complaints - all grades) | No Evidence Yet | N/A |
| People with oral cavity or oropharyngeal cancers | Recombinant Interleukin (rIL-2) + standard therapy (surgery) | Standard therapy (surgery) alone | Overall survival | Very Low | Not specified |
| People with oral cavity or oropharyngeal cancers | Recombinant Interleukin (rIL-2) + standard therapy (surgery) | Standard therapy (surgery) alone | Disease-free survival | Very Low | Not specified |
| People with oral cavity or oropharyngeal cancers | Tyrosine kinase inhibitors (erlotinib gefitinib or lapatinib) + standard therapy (either RT or CRT) | Standard therapy (either RT or CRT alone) | Progression-free Survival | Very Low | Not specified |
| People with oral cavity or oropharyngeal cancers | Tyrosine kinase inhibitors (erlotinib gefitinib or lapatinib) + standard therapy (either RT or CRT) | Standard therapy (either RT or CRT alone) | Locoregional control | Very Low | Not specified |
| People with oral cavity or oropharyngeal cancers | Tyrosine kinase inhibitors (erlotinib gefitinib or lapatinib) + standard therapy (either RT or CRT) | Standard therapy (either RT or CRT alone) | Overall survival | Very Low | Not specified |
| People with oral cavity or oropharyngeal cancers | Tyrosine kinase inhibitors (erlotinib gefitinib or lapatinib) + standard therapy (either RT or CRT) | Standard therapy (either RT or CRT alone) | Disease-free Survival | Very Low | Not specified |
CD010403
Current Version: CD010403.PUB3
| 1 older version
Current Evidence Gaps 6 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Long-term skeletal relapse | Very Low | Not specified |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Psychological status | Very Low | Not specified |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Velopharyngeal function | Very Low | Not specified |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Speech (deterioration) | Very Low | Not specified |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Clinical morbidities | Very Low | Not specified |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Maxillary advancement | Very Low | Not specified |
Previous Versions
CD010403.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Maxillary advancement | Very Low | - |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Long-term skeletal relapse | Very Low | - |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Speech (deterioration) | Very Low | - |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Velopharyngeal function | Very Low | - |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Psychological status | Very Low | - |
| Cleft patients | Maxillary distraction osteogenesis | Orthognathic surgery | Clinical morbidities | Very Low | - |
CD010431
Current Version: CD010431.PUB2
Current Evidence Gaps 1 gap
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| people with dental decay on proximal surfaces of primary and permanent teeth | different microâinvasive methods (e.g. resin infiltration resin sealant sealant patch and glass ionomer) | nonâinvasive treatments (e.g. fluoride varnish advice to floss) | Caries progression measured by DSR > pairwise > visual scoring (12 months to 36 months followâup) | Moderate | Not specified |
| people with dental decay on proximal surfaces of primary and permanent teeth | different microâinvasive methods (e.g. resin infiltration resin sealant sealant patch and glass ionomer) | nonâinvasive treatments (e.g. fluoride varnish advice to floss) | Change in decayed, missing and filled (DMF/dmf) figures at surface, tooth and whole mouth level. | No Evidence Yet | N/A |
CD010470
Current Version: CD010470.PUB3
| 1 older version
Current Evidence Gaps 7 gaps
| Population | Intervention | Comparison | Outcome | Evidence Level | Downgrade Reason |
|---|---|---|---|---|---|
| idiopathic dysgeusia combined with hypogeusia | acupuncture | sham control | Taste discrimination assessed with 32 taste strips with a follow-up of 8 weeks | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder | zinc | placebo | Taste acuity improvement (patient-reported outcome) assessed with VAS/questionnaire where improvement in dysgeusia is defined as more than 5% improvement in the VAS scores for a mean follow-up period of 3 months | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder | zinc | placebo | Taste acuity improvement (objective outcome - dichotomous data) assessed with filter paper disk and Henkin's 3-drop stimulus method for a mean follow-up period of 3 months | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder | zinc | placebo | Cross-over trial - taste detection assessed with Henkin's method for a follow-up period of 6 months | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder | zinc | placebo | Cross-over trial - taste recognition assessed with Henkin's method for a follow-up period of 6 months | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder | zinc | placebo | Taste acuity improvement (objective outcome - continuous data) assessed with filter paper strip and filter paper disk methods for a mean follow-up period of 3 months | Very Low | Not specified |
| patients with taste disturbances, zinc-deficient/idiopathic taste disorder and taste disorder secondary to chronic renal failure | zinc | placebo | Adverse events - follow-up range 12 weeks to 18 weeks | Very Low | Not specified |
Previous Versions
CD010470.PUB2
| Population | Intervention | Comparison | Outcome | Evidence Level | Studies |
|---|---|---|---|---|---|
| patients with taste disturbances | acupuncture | sham control | Taste discrimination | Low | - |
| patients with taste disturbances | zinc | placebo | Taste acuity improvement - Objective outcome - Dichotomous - Idiopathic and zinc deficient taste disorders | Low | - |
| patients with taste disturbances | zinc | placebo | Taste acuity improvement - Objective outcome - Continuous - Overall taste improvement | Moderate | - |
| patients with taste disturbances | zinc | placebo | Adverse events | No Evidence Yet | - |
| patients with taste disturbances | zinc | placebo | Taste acuity improvement - Patient reported outcome | Very Low | - |
| patients with taste disturbances | zinc | placebo | Taste acuity improvement - Objective outcome - Continuous - Taste recognition | Very Low | - |
Showing 161 to 180 of 214 review series
Summary Statistics
214
Review Series
3688
PICO Questions
Evidence Certainty
High
(%)
Moderate
(%)
Low
(%)
Very Low
(%)
No Evidence Yet
(%)
GRADE Downgrading Reasons
Risk of Bias
985
(85.8%)
Imprecision
895
(78.0%)
Inconsistency
253
(22.0%)
Indirectness
188
(16.4%)
Publication Bias
48
(4.2%)